化合物RO 5-3335
| 中文名称 | 化合物RO 5-3335 |
|---|---|
| 中文同义词 | 化合物RO 5-3335;RO 5-3335,核心结合因子抑制剂;7-氯-5-(1H-吡咯-2-基)-1H-苯并[E][1,4]二氮杂卓-2(3H)-酮 |
| 英文名称 | Ro 5-3335 |
| 英文同义词 | Ro 5-3335;7-Chloro-2-oxo-5-(1H-pyrrol-2-yl)-2,3-dihydro-1H-1,4-benzodiazepine;NSC-66020;7-Chloro-1,3-dihydro-5-(1H-pyrrol-2-yl)-2H-1,4-benzodiazepin-2-one;CBFβ-Runx1 inhibitor II;2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-5-(1H-pyrrol-2-yl)-;7-Chloro-5-(1H-pyrrol-2-yl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one;7-Chloro-5-(1H-pyrrol-2-yl)-1H-benzo[e][1,4]diazepin-2(3H)-one |
| CAS号 | 30195-30-3 |
| 分子式 | C13H10ClN3O |
| 分子量 | 259.69 |
| EINECS号 | |
| 相关类别 | 标准品 |
| Mol文件 | 30195-30-3.mol |
| 结构式 |  |
化合物RO 5-3335 性质
| 熔点 | 256 °C(dec.) |
|---|---|
| 溶解度 | 在 DMSO 中溶解度为 100 mM |
| 形态 | 粉末晶体 |
| 颜色 | 白色至浅红色至绿色 |
RUNX1-CBFβ interaction
Ro5-3335 has antiproliferative activity against human CBF leukemia cell lines, with IC
50
s of 1.1 μM, 21.7 μM and 17.3 μM for ME-1, Kasumi-1 and REH, respectively.
Ro5-3335 inhibits definitive hematopoiesis in zebrafish embryos.
Ro5-3335 does not completely break apart RUNX1-CBFβ interaction, but changes the conformation of their complex or increases the distance between RUNX1 and CBFβ in the complex.
Ro5-3335 is identified as an inhibitor of RUNX1–CBFβ function in zebrafish models.
Ro5-3335 rescues preleukemic phenotype in a RUNX1-ETO transgenic zebrafish.
Ro5-3335 (300 mg/kg/d; p.o; for 30 days) reduces leukemia burden in a mouse CBFB-MYH11 leukemia model.
| Animal Model: | C57BL/6 mice (leukemic model) |
| Dosage: | 300 mg/kg |
| Administration: | Oral administration; daily; for 30 days |
| Result: | Reduced the number of c-kit + cells in the transplanted mice and leukemic cell infiltration in the livers, bone marrow and spleen. |
安全信息
| 海关编码 | 2933.99.8290 |
|---|
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/08/19 | HY-108470 | Ro5-3335 | 1 mg | 545元 | |
| 2024/08/19 | HY-108470 | 化合物RO 5-3335 Ro5-3335 | 30195-30-3 | 5mg | 1200元 |