8-BROMO-ATP
中文名称 | 8-BROMO-ATP |
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中文同义词 | |
英文名称 | 8-bromoadenosine 5'-triphosphate |
英文同义词 | 8-bromoadenosine 5'-triphosphate;Adenosine 5'-(tetrahydrogen triphosphate), 8-bromo- |
CAS号 | 23567-97-7 |
分子式 | C10H15BrN5O13P3 |
分子量 | 586.08 |
EINECS号 | |
相关类别 | |
Mol文件 | 23567-97-7.mol |
结构式 |
8-BROMO-ATP 性质
沸点 | 983.1±75.0 °C(Predicted) |
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密度 | 2.85±0.1 g/cm3(Predicted) |
酸度系数(pKa) | 0.97±0.50(Predicted) |
8-Bromo-ATP (8-Bromoadenosine 5'-triphosphate),一种 ATP 类似物,是一种嘌呤能 P2X receptor 受体的激动剂。8-Bromo-ATP 对多发性骨髓瘤细胞具有细胞毒性,IC50 为 23.1 μM。
8-Bromo-ATP (10-50 μM; 5 days) treatment shows cytotoxic to multiple myeloma.
Fluorescence measurements are made possible through the use of 8-Bromo-ATP, which selectively quenched certain tryptophan residues of the ATPase. 8-Bromo-ATP enhances the rate of dephosphorylation of native ATPase 2-3-fold when added in the absence of divalent cations.
Cell Viability Assay
Cell Line: | MM 1.s cells |
Concentration: | 10 μM, 20 μM, 30 μM, 40 μM, 50 μM |
Incubation Time: | 5 days |
Result: | Showed cytotoxic to multiple myeloma. |