SDZ-MKS 492
中文名称 | SDZ-MKS 492 |
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中文同义词 | 化合物 T12873 |
英文名称 | SDZ MKS 492 |
英文同义词 | SDZ MKS 492;MKS 492;1H-Purine-2,6-dione, 8-[[(1R)-1-(3,4-dimethoxyphenyl)-2-hydroxyethyl]amino]-3,7-dihydro-7-(2-methoxyethyl)-1,3-dimethyl-;SDZ MKS 492,SDZMKS 492 |
CAS号 | 114606-56-3 |
分子式 | C20H27N5O6 |
分子量 | 433.46 |
EINECS号 | |
相关类别 | |
Mol文件 | 114606-56-3.mol |
结构式 |
SDZ-MKS 492 性质
沸点 | 648.7±65.0 °C(Predicted) |
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密度 | 1.36±0.1 g/cm3(Predicted) |
储存条件 | Store at -20°C |
溶解度 | DMSO:250 mg/mL(576.75 mM;需要超声波) |
形态 | 固体 |
酸度系数(pKa) | 14.25±0.10(Predicted) |
颜色 | 白色至米白色 |
type III phosphodiesterase
MKS 492 relaxes airway smooth muscle in vitro.
MKS-492 (3-10 mg/kg; i.v.) inhibits antigen-induced bronchoconstriction in guinea pigs.
MKS-492 (1-3 mg/kg; i.v.) inhibits PAF-induced bronchoconstriction and the increase in airway responsiveness to histamine in guinea pigs.
MKS-492 (30-100 mg/kg; i.p.) inhibits leukotriene B4 (LTB4)-induced airway eosinophilia in guinea pigs.
MKS-492 (10-100 mg/kg; i.p.) inhibits passive cutaneous anaphylaxis and mediator-induced skin reactions in rats.
Animal Model: | Female Hartley guinea pigs (250-300 g) were passively sensitized with anti-BPO BGG guinea pig serum |
Dosage: | 3, 10 mg/kg |
Administration: | I.v. 5 min before antigen challenge |
Result: | Inhibited antigen-induced bron choconstriction in a dose-related manner. |
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/04/30 | HY-100164 | SDZ-MKS 492 | 1 mg | 1590元 | |
2024/04/30 | HY-100164 | SDZ-MKS 492 SDZ-MKS 492 | 114606-56-3 | 5mg | 3500元 |