S-[(1E)-1;2-DICHLOROETHENYL]--L-CYSTEINE
中文名称 | S-[(1E)-1;2-DICHLOROETHENYL]--L-CYSTEINE |
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中文同义词 | S-(E-1,2-二氯乙烯基)-L-半胱氨酸 |
英文名称 | S-(E-1,2-DICHLOROVINYL)-L-CYSTEINE |
英文同义词 | DCVC (E-isomer);2-amino-3-[(E)-1,2-dichloroethenyl]sulfanylpropanoic acid;DCVC (S-[(1E)-1,2-dichloroethenyl]--L-cysteine);2-dichloroethenyl]--L-cysteine;S-[(1E)-1;S-[(1E)-1;2-DICHLOROETHENYL]--L-CYSTEINE;L-Cysteine, S-[(1E)-1,2-dichloroethenyl]- |
CAS号 | 13419-46-0 |
分子式 | C5H7Cl2NO2S |
分子量 | 216.09 |
EINECS号 | |
相关类别 | |
Mol文件 | 13419-46-0.mol |
结构式 | ![]() |
S-[(1E)-1;2-DICHLOROETHENYL]--L-CYSTEINE 性质
熔点 | 155-156 °C (decomp) |
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沸点 | 339.7±42.0 °C(Predicted) |
密度 | 1.437 (estimate) |
折射率 | 1.6100 (estimate) |
储存条件 | Store at -20°C |
溶解度 | DMSO:23 mg/mL (106.44 mM);水:1.034 mg/mL (4.79 mM) |
形态 | 固体 |
酸度系数(pKa) | 2.01±0.10(Predicted) |
颜色 | 白色至米白色 |
Extraplacental membranes are cultured for 4, 8, and 24h with the trichloroethylene (TCE) metabolite S-(1,2-dichlorovinyl)-l-cysteine (DCVC) in the absence or presence of lipoteichoic acid (LTA) or lipopolysaccharide (LPS) to simulate infection. In addition, membranes were cocultured with DCVC and Group B Streptococcus (GBS). DCVC (5-50μM) significantly inhibited LTA-, LPS-, and GBS-stimulated cytokine release from tissue cultures as early as 4h. DCVC inhibits pathogen-stimulated cytokine (IL-1β, IL-8, and TNF-α) release in a concentration-dependent manner.