| Company Name: |
Sigma-Aldrich
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| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
| Products Intro: |
Product Name:Monoclonal Anti-Calpastatin antibody produced in mouse
Purity:clone 1F7E3D10, ascites fluid, buffered aqueous solution Package:100UL Remarks:C270-100UL
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| Company Name: |
Riedel-de Haen AG
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| Tel: |
800 558-9160 |
| Email: |
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| Products Intro: |
Remarks:clone 1F7E3D10, ascites fluid, buffered aqueous solution
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| Company Name: |
Alexis Corporation
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| Tel: |
+41 61 926 8989 |
| Email: |
alexis-ch@alexis-corp.ch |
| Products Intro: |
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| | ANTI-CALPASTATIN Basic information |
| Product Name: | ANTI-CALPASTATIN | | Synonyms: | ANTI-CALPASTATIN MOUSE MAB;ANTI-CALPASTATIN;ANTI-CALPASTATIN (DOMAIN II);ANTI-CALPASTATIN (DOMAIN IV);ANTI-CALPASTATIN, DOMAIN IV, BOVINE;ANTI-CALPASTATIN, DOMAIN IV, BOVINE (MOUSE);ANTI-CALPASTATIN, DOMAIN IV MOUSE MAB;ANTI-CALPASTATIN, HUMAN | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![ANTI-CALPASTATIN Structure]() |
| | ANTI-CALPASTATIN Chemical Properties |
| storage temp. | −20°C | | form | buffered aqueous solution |
| | ANTI-CALPASTATIN Usage And Synthesis |
| Uses | Monoclonal Anti-Calpastatin antibody produced in mouse is suitable for indirect immunofluorescence at a dilution of 1:200 and for western blotting at a dilution of 1:5,000. | | General Description | Calpastatin is a protein encoded by the CAST gene in humans. Calpastatin is an endogenous inhibitor of the ubiquitous calcium dependent proteinases μ- and m-calpain. It plays a key role in many cellular physiological and pathological processes. Calpastatin level is very important for controlling calpain activity. | | Biochem/physiol Actions | Calpastatin availability in cytosol is controlled by Ca2+ and cyclic AMP. Prolonged calpain activation promotes degradation of calpastatin. Calpastatin is found to be overexpressed in mycoplasma-contaminated cultured cells. CAST gene is found to be involved in genetic susceptibility to Keratoconus (KC), a genetically heterogeneous corneal dystrophy. It is also found to be associated with Parkinson′s disease (PD) and single nucleotide polymorphisms (SNPs). |
| | ANTI-CALPASTATIN Preparation Products And Raw materials |
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