- Ecallantide
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- $0.00 / 1g
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2024-07-25
- CAS:460738-38-9
- Min. Order: 1g
- Purity: 98%min
- Supply Ability: 1000g
- ecallantide
-
- $10.00 / 1kg
-
2024-03-08
- CAS:460738-38-9
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 1000kg
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| | ecallantide Basic information |
| Product Name: | ecallantide | | Synonyms: | ecallantide;DX 88;ecallantide USP/EP/BP;Cys16-Cys40;Cys32-Cys53);H-Glu-Ala-Met-His-Ser-Phe-Cys-Ala-Phe-Lys-Ala-Asp-Asp-Gly-Pro-Cys-Arg-Ala-Ala-His-Pro-Arg-Trp-Phe-Phe-Asn-Ile-Phe-Thr-Arg-Gln-Cys-Glu-Glu-Phe-Ile-Tyr-Gly-Gly-Cys-Glu-Gly-Asn-Gln-Asn-Arg-Phe-Glu-Ser-Leu-Glu-Glu-Cys-Lys-Lys-Met-Cys-Thr-Arg-Asp-OH(Disulfide bridge：Cys7-Cys57 | | CAS: | 460738-38-9 | | MF: | C305H442N88O91S8 | | MW: | 7053.82798 | | EINECS: | | | Product Categories: | | | Mol File: | 460738-38-9.mol |  |
| | ecallantide Chemical Properties |
| | ecallantide Usage And Synthesis |
| Description | Ecallantide, also known as DX-88, was approved in 2009 in the
United States for treatment of hereditary angioedema (HAE), a condition
characterized by episodic attacks of localized edema in cutaneous
and mucosal tissues. HAE results from deficiencies or disorders of C1-esterase inhibitor protein (C1-
1NH). Mutation of the gene that encodes C1-1NH causes the lack or
altered activity of the serine protease, C1-1NH. C1-1NH regulates the
kallikrein–kinin (contact activation) and complement cascade systems.
Ecallantide (DX-88) was designed to inhibit the action of
plasma kallikrein. Ecallantide is a potent and selective inhibitor of
plasma kallikrein with a Ki= 25 pM. The discovery program that
identified ecallantide used phage display technology and a library of
designed variants of the first Kunitz domain of TFPI. Ecallantide, a
60-amino acid peptide, with 3-disulfide bonds, differs from TFPI by
7-amino acids. Ecallantide has been developed as a subcutaneous
administered formulation. | | Originator | Dyax Corp. (United States) | | Uses | Treatment of hereditary angioedema; reduction of blood loss during cardiothoracic surgery (plasma kallikrein inhibitor). | | Brand name | Kalbitor |
| | ecallantide Preparation Products And Raw materials |
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