HS014
| 中文名称 | HS014 |
|---|---|
| 中文同义词 | N-乙酰基-L-半胱氨酰-L-A-谷氨酰-L-组氨酰-3-(2-萘基)-D-丙氨酰-L-精氨酰-L-色氨酰甘氨酰-L-半胱氨酰-L-脯氨酰-L-脯氨酰-L-赖氨酰-L-A-天冬氨酰胺环(1->8)-二硫醚;AC-CYS-GLU-HIS-D-2-NAL-ARG-TRP-GLY-CYS-PRO-PRO-LYS-ASP-NH2(DISULFIDE BRIDGE:CYS1-CYS8);受体拮抗剂多肽HS014 |
| 英文名称 | HS014 |
| 英文同义词 | AC-CYS-GLU-HIS-D-2-NAL-ARG-TRP-GLY-CYS-PRO-PRO-LYS-ASP-NH2;AC-CYS-GLU-HIS-D-NAL(2)-ARG-TRP-GLY-CYS-PRO-PRO-LYS-ASP-NH2;(AC-CYS11,D-2-NAL14,CYS18)-BETA-MSH (11-22) AMIDE;(AC-CYS11,D-ALA(2-NAPHTHYL)14,CYS18)-BETA-MSH (11-22) AMIDE;[ACETYL-CYS11, B-(2-NAPHTHYL)-D-ALA14, CYS18]-BETA-MELANOCYTE STIMULATING HORMONE FRAGMENT 11-22;M.W. 1563.77 C71H94N20O17S2;Acetyl-(Cys11,D-2-Nal14,Cys18)-β-MSH (11-22) aMide HS014;Ac-Cys-Glu-His-D-Nal(2)-Arg-Trp-Gly-Cys-Pro-Pro-Lys-Asp-NH2 (Disulfide bridge Cys1-Cys8) |
| CAS号 | 207678-81-7 |
| 分子式 | C71H94N20O17S2 |
| 分子量 | 1563.76 |
| EINECS号 | |
| 相关类别 | 标准品;Melanocortin receptor |
| Mol文件 | 207678-81-7.mol |
| 结构式 |  |
HS014 性质
| 密度 | 1.57±0.1 g/cm3(Predicted) |
|---|---|
| 储存条件 | −20°C |
| 形态 | 固体 |
| 酸度系数(pKa) | 4.07±0.10(Predicted) |
| 水溶解性 | Soluble to 1 mg/ml in water |
HS014 是一种高效、选择性的黑素皮质素-4 (MC4) 受体拮抗剂，对人 MC4、MC1、MC3 和 MC5 受体的 Ki 值分别为 3.16、108、54.4 和 694 nM。HS014 调节吗啡对小鼠行为的影响。HS014 增加自由喂养大鼠的食物摄取量。
The dose-effect curve of morphine for locomotor activity was shifted downwards in C57Bl/6 mice pretreated with HS014 and in A(y) mice. The dose-effect curve of morphine for antinociception is shifted two- and threefold to the left in C57Bl/6 mice pretreated with HS014 and in A(y) mice, respectively.
Pretreatment with HS014 blocks the effect of IL-1beta on food intake and respiratory exchange ratio (RER) at later time points (beyond 8 h post injection), as well as the hypoactivity and increases metabolic rate.
安全信息
| 安全说明 | 22-24/25 |
|---|---|
| WGK Germany | 3 |
| 提供商 | 语言 |
|---|---|
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英文
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| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2023/03/20 | HY-P1216 | HS014 HS014 | 207678-81-7 | 1 mg | 4500元 |
| 2023/03/20 | HY-P1216 | HS014 HS014 | 207678-81-7 | 5 mg | 13500元 |