3-Iodobenzaldehyde[4-(diphenylamino)-6-(4-morpholinyl)-1,3,5-triazin-2-yl]hydrazone
中文名称 | 3-Iodobenzaldehyde[4-(diphenylamino)-6-(4-morpholinyl)-1,3,5-triazin-2-yl]hydrazone |
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中文同义词 | 化合物VACUOLIN-1;4-(2-(3-碘亚苄基)肼基)-6-吗啉-N,N-二苯基-1,3,5-三嗪环-2-胺;VACUOLIN 1;VACUOLIN1 |
英文名称 | 3-Iodobenzaldehyde[4-(diphenylamino)-6-(4-morpholinyl)-1,3,5-triazin-2-yl]hydrazone |
英文同义词 | 3-Iodobenzaldehyde[4-(diphenylamino)-6-(4-morpholinyl)-1,3,5-triazin-2-yl]hydrazone;(E)-4-(2-(3-iodobenzylidene)hydrazinyl)-6-Morpholino-N,N-diphenyl-1,3,5-triazin-2-aMine;Vacuolin-1;4-(2-(3-Iodobenzylidene)hydrazinyl)-6-morpholino-N,N-diphenyl-1,3,5-triazin-2-amine;Benzaldehyde, 3-iodo-, 2-[4-(diphenylamino)-6-(4-morpholinyl)-1,3,5-triazin-2-yl]hydrazone;Vacuolin-1 - CAS 351986-85-1 - Calbiochem;4-[(2E)-2-(3-iodobenzylidene)hydrazinyl]-6-(morpholin-4-yl)-N,N-diphenyl-1,3,5-triazin-2-amine;Inhibitor,Fab1,Vacuolin1,Autophagy,Vacuolin 1,PIKfyve,membrane repair,Vacuolin-1,inhibit,exocytosis,HeLa cells |
CAS号 | 351986-85-1 |
分子式 | C26H24IN7O |
分子量 | 577.42 |
EINECS号 | |
相关类别 | 抑制剂 |
Mol文件 | 351986-85-1.mol |
结构式 | ![]() |
3-Iodobenzaldehyde[4-(diphenylamino)-6-(4-morpholinyl)-1,3,5-triazin-2-yl]hydrazone 性质
沸点 | 719.7±70.0 °C(Predicted) |
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密度 | 1.53±0.1 g/cm3(Predicted) |
储存条件 | 2-8°C |
溶解度 | DMSO:18.33(最大浓度 mg/mL);31.74(最大浓度 mM) DMSO:PBS (pH 7.2) (1:7):0.12(最大浓度 mg/mL);0.21(最大浓度.mM) DMF:3.0(最大浓度 mg/mL);5.2(最大浓度 mM) |
形态 | 白色固体 |
酸度系数(pKa) | 10.74±0.10(Predicted) |
颜色 | 白色至米白色 |
Target | Value |
PIKfyve
() |
Vacuolin-1 (1 μM; Pretreatment 1 hour) blocks ionomycin-induced exocytosis of lysosomes but not of enlargeosomes. It results in vacuolation of lysosomes (A) and complete inhibition of the surface expression of Lamp-1. Vacuolin-1 (1 μM; 20-180 min) disrupts the segregation of inner and limiting membranes characteristic of endosomes and lysosomes. Ultrastructural analysis also shows that vacuolin-1 favours fusion of inner and limiting membranes. Vacuolin-1 (5 or 10 μM; 2 hours) blocks the Ca 2+ -dependent release of β-hexosaminidase from lysosomes. In HeLa cells, ionomycin results in the expected release of 18-20% of lysosomal β-hexosaminidase. But when cells pretreated with vacuolin-1, releases no more β-hexosaminidase compared with cells that are not exposed to ionomycin (4%).
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/04/30 | HY-118630 | 3-Iodobenzaldehyde[4-(diphenylamino)-6-(4-morpholinyl)-1,3,5-triazin-2-yl]hydrazone Vacuolin-1 | 351986-85-1 | 5mg | 900元 |
2024/04/30 | S6912 | 3-Iodobenzaldehyde[4-(diphenylamino)-6-(4-morpholinyl)-1,3,5-triazin-2-yl]hydrazone Vacuolin-1 | 351986-85-1 | 5mg | 958.24元 |