| Company Name: |
Riedel-de Haen AG
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| Tel: |
800 558-9160 |
| Email: |
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| Products Intro: |
Remarks:clone 3B10, purified immunoglobulin, buffered aqueous solution
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| Company Name: |
SIGMA-RBI
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| Tel: |
800 736 3690 (Orders) |
| Email: |
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| Products Intro: |
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| | Anti-CAML1, Anti-L1 Cell Adhesion Molecule, Anti-MIC5, Anti-Neural Cell Adhesion Molecule L1 Basic information |
| | Anti-CAML1, Anti-L1 Cell Adhesion Molecule, Anti-MIC5, Anti-Neural Cell Adhesion Molecule L1 Chemical Properties |
| | Anti-CAML1, Anti-L1 Cell Adhesion Molecule, Anti-MIC5, Anti-Neural Cell Adhesion Molecule L1 Usage And Synthesis |
| General Description | The gene L1CAM (L1 cell adhesion molecule) encodes a member of the immunoglobulin supergene family. The encoded protein contains a cytoplasmic intracellular domain, one single-pass transmembrane region and an extracellular domain containing six immunoglobulin- (Ig) and five fibronectin (Fn) III-like motifs. The gene is mapped to human chromosome Xq28. It contains 29 exons that encode a protein of 1257 amino acids containing a 19 amino acid signal peptide and a functional L1 protein of 1238 amino acids. It is mainly expressed in the nervous system. | | Biochem/physiol Actions | The gene L1CAM (L1 cell adhesion molecule) encodes a glycoprotein that functions in axon growth during development and axon bundling. It interacts with Schwann cells and axons, and mediates neuronal cell migration, and neuronal cell survival. Overexpression of this protein is associated with tumor progression. It has been found to mediate therapeutic resistance in ovarian and pancreatic cancer cells. |
| | Anti-CAML1, Anti-L1 Cell Adhesion Molecule, Anti-MIC5, Anti-Neural Cell Adhesion Molecule L1 Preparation Products And Raw materials |
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