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| (3R)-1-[(20S)-20-(Dimethylamino)-4-oxo-5α-pregnan-3β-yl]-3-isopropylazetidin-2-one Basic information |
| (3R)-1-[(20S)-20-(Dimethylamino)-4-oxo-5α-pregnan-3β-yl]-3-isopropylazetidin-2-one Chemical Properties |
Melting point | 220-4°C | Boiling point | 560.7±25.0 °C(Predicted) | density | 1.060±0.06 g/cm3(Predicted) | pka | 9.60±0.50(Predicted) |
| (3R)-1-[(20S)-20-(Dimethylamino)-4-oxo-5α-pregnan-3β-yl]-3-isopropylazetidin-2-one Usage And Synthesis |
Description | This alkaloid is the major base found in Pachysandra terminalis Sieb. et Zucco
Like the other alkaloids present in this plant, it contains the pregnane skeleton.
It is dextrorotatory with [α]D + 24° (CHCI 3). It has two keto groups in the
molecule, one being present in a four-membered ring. Reduction with NaBH4
furnishes Pachystermine B (q.v.). The structure has been confirmed by the partial
synthesis of the alkaloid. | References | Kikuchi, Uyeo., Tetrahedron Lett., 3473 (1965)
Kikuchi, Uyeo., Chem. Pharm. Bull., 15, 549 (1967)
Partial synthesis:
Kikuchi et al., Tetrahedron Lett., 909 (1968) |
| (3R)-1-[(20S)-20-(Dimethylamino)-4-oxo-5α-pregnan-3β-yl]-3-isopropylazetidin-2-one Preparation Products And Raw materials |
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