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| methyl 6-(bromomethyl)nicotinate Basic information |
Product Name: | methyl 6-(bromomethyl)nicotinate | Synonyms: | methyl 6-(bromomethyl)nicotinate;6-Bromomethyl-nicotinic acid methyl ester;3-Pyridinecarboxylic acid, 6-(broMoMethyl)-;6-(bromomethyl)-3-pyridinecarboxylic acid methyl ester;Methyl 2-(bromomethyl)pyridine-5-carboxylate;6-Bromomethylpyridin-3-carboxylic acid methyl ester;3-Pyridinecarboxylic acid, 6-(bromomethyl)-, methyl ester | CAS: | 131803-48-0 | MF: | C8H8BrNO2 | MW: | 230.06 | EINECS: | | Product Categories: | | Mol File: | 131803-48-0.mol | ![methyl 6-(bromomethyl)nicotinate Structure](CAS/GIF/131803-48-0.gif) |
| methyl 6-(bromomethyl)nicotinate Chemical Properties |
Boiling point | 284.9±30.0℃ (760 Torr) | density | 1.533±0.06 g/cm3 (20 ºC 760 Torr) | Fp | 126.1±24.6℃ | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | pka | 1.40±0.22(Predicted) | form | solid | color | OFF WHITE |
HazardClass | IRRITANT | HS Code | 29333990 |
| methyl 6-(bromomethyl)nicotinate Usage And Synthesis |
Uses | methyl 6-(bromomethyl)nicotinate is an organic reagent mainly used in chemical and scientific laboratory research. | Synthesis | methyl 6-(bromomethyl)nicotinate is synthesised using methyl 6-methylnicotinate as a raw material by chemical reaction. The specific synthesis steps are as follows: 0.471 g (1.0 equivalent) of N-bromosuccinimide and 64 mg (0.1 equivalent) of benzoyl peroxide are added to a solution of 0.4 g of the product obtained in the preceding Stage 1 in 15 ml of carbon tetrachloride. The solution is brought to reflux for 6 hours, then filtered and evaporated under reduced pressure. The residue is purified by chromatography on silica gel (dichloromethane/ethyl acetate: 95/5) to produce 0.262 g of the expected product. [ Yield: 43percent MS: MH+ 231].
![methyl 6-(bromomethyl)nicotinate synthesis methyl 6-(bromomethyl)nicotinate synthesis](/NewsImg/2024-04-08/6384818242878208491887435.png) |
| methyl 6-(bromomethyl)nicotinate Preparation Products And Raw materials |
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