5-Maleimidovalericacid-NHS manufacturers
- Mal-C2-NHS ester
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- $31.00 / 2mg
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2024-10-28
- CAS:103750-03-4
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | 5-Maleimidovalericacid-NHS Basic information |
| Product Name: | 5-Maleimidovalericacid-NHS | | Synonyms: | 5-Maleimidovalericacid-NHS;5-Maleimidopentanoic acid-NHS ester;1H-Pyrrole-1-pentanoicacid, 2,5-dihydro-2,5-dioxo-, 2,5-dioxo-1-pyrrolidinyl ester;2,5-dioxopyrrolidin-1-yl 5-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl);Mal-C2-NHS ester;2,5-dioxopyrrolidin-1-yl 5-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)pentanoate;5-Maleimido-pentanoic NHS ester;5-maleimevulinic acid NHS | | CAS: | 103750-03-4 | | MF: | C13H14N2O6 | | MW: | 294.26 | | EINECS: | | | Product Categories: | | | Mol File: | 103750-03-4.mol |  |
| | 5-Maleimidovalericacid-NHS Chemical Properties |
| Boiling point | 472.3±47.0 °C(Predicted) | | density | 1.44±0.1 g/cm3(Predicted) | | solubility | Soluble in DMSO, DCM, DMF | | pka | -2.23±0.20(Predicted) | | form | Solid | | color | White to light yellow | | InChI | InChI=1S/C13H14N2O6/c16-9-4-5-10(17)14(9)8-2-1-3-13(20)21-15-11(18)6-7-12(15)19/h4-5H,1-3,6-8H2 | | InChIKey | ULZJAHZPCLFGHQ-UHFFFAOYSA-N | | SMILES | N1(CCCCC(ON2C(=O)CCC2=O)=O)C(=O)C=CC1=O |
| Safety Statements | 24/25 | | HS Code | 29212900 |
| | 5-Maleimidovalericacid-NHS Usage And Synthesis |
| Description | 5-Maleimido-pentanoic NHS ester contains a maleimide group and an NHS ester. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. | | Chemical Properties | White powder | | Uses | Mal-C2-NHS ester is a noncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. | | IC 50 | Non-cleavable Linker | | References | [1] Andrew Wood, et al. Processes for the synthesis and purification of heterobifunctional cross-linkers. WO2011023680A2. |
| | 5-Maleimidovalericacid-NHS Preparation Products And Raw materials |
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