ICI 118,551 HYDROCHLORIDE
| 中文名称 | ICI 118,551 HYDROCHLORIDE |
|---|---|
| 中文同义词 | ICI 118551 盐酸盐;反式-3-(异丙基氨基)-1-((7-甲基-2,3-二氢-1H-茚-4-基)氧基)丁烷-2-醇盐酸盐 |
| 英文名称 | (±)-erythro-(S*,S*)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanolhydrochloride |
| 英文同义词 | ICI 118,551 hydrochloride, >=98%;(±)-erythro-(S*,S*)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanolhydrochloride;(2R,3R)-rel-1-[(2,3-Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanol hydrochloride (1:1);CS-769;CI 118551 Hydrochloride;551 hydrochloride;ICI 118;ICI118551,ICI 118,551 hydrochloride,ICI 118551,Adrenergic Receptor,ICI-118551,Inhibitor,Beta Receptor,inhibit,ICI 118,551 |
| CAS号 | 72795-01-8 |
| 分子式 | C17H28ClNO2 |
| 分子量 | 313.87 |
| EINECS号 | |
| 相关类别 | Aromatics;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals |
| Mol文件 | 72795-01-8.mol |
| 结构式 |  |
ICI 118,551 HYDROCHLORIDE 性质
| 储存条件 | desiccated |
|---|---|
| 溶解度 | DMSO : 25 mg/mL (79.65 mM; 需要超声波)H2O : 12.5 mg/mL (39.83 mM; 需要超声波) |
| 形态 | 粉末 |
| 颜色 | 白色 |
Ki: 0.7nM (β2 receptor), 49.5 nM (β1 receptor), 611 nM (β3 receptor)
ICI 118551 inhibits cAMP accumulation with IC 50 of 1.7 μM in IMCD cells. ICI 118551 (10 μM) induces a prominent vasorelaxation of norepinephrine (NE)-precontracted PA but not AO. In failing human heart, ICI 118551 has significant effects on beat duration, with time-to-peak contraction and time-to-90% relaxation reduced compared with basal contraction. Negative Inotropic Effect of ICI 118551 Is Not cAMP-Related. Overexpression of β2AR in rabbit myocytes enhances negative inotropic effects of ICI 118551.
ICI 118551 (0.2 mg/kg) injected into the jugular vein of the mice, reduces systolic pressure in the pulmonary circuit but not systemic arterial pressure.
安全信息
| WGK Germany | 3 |
|---|
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | S8114 | ICI 118,551 HYDROCHLORIDE ICI-118551 Hydrochloride | 72795-01-8 | 5mg | 1613.61元 |
| 2024/04/30 | S8114 | Zenidolol (ICI-118551) Hydrochloride | 72795-01-8 | 10mM (1mL in DMSO) | 1875.51元 |