| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:CAY10589
CAS:1077626-52-8
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
4008200310 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:CAY10589;CAY10589
CAS:1077626-52-8
Purity:98% Package:25 mg
|
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| | CAY10589 Basic information |
| Product Name: | CAY10589 | | Synonyms: | CAY10589;CAY10589 Exclusive;FQMPYBCEABTPIK-UHFFFAOYSA-N;Octanoic acid, 2-[[4-[([1,1'-biphenyl]-4-ylmethyl)amino]-6-chloro-2-pyrimidinyl]thio]- | | CAS: | 1077626-52-8 | | MF: | C25H28ClN3O2S | | MW: | 470.03 | | EINECS: | | | Product Categories: | | | Mol File: | 1077626-52-8.mol |  |
| | CAY10589 Chemical Properties |
| Boiling point | 648.1±55.0 °C(Predicted) | | density | 1.27±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 20 mg/ml; DMSO: 20 mg/ml; DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml; Ethanol: 10 mg/ml | | form | A crystalline solid | | pka | 3.04±0.21(Predicted) |
| | CAY10589 Usage And Synthesis |
| Description | Microsomal Prostaglandin E2 Synthase-1 (mPGES-1), with cyclooxygenase-2 (COX-2), synthesizes PGE2, which is directly involved in signaling during inflammation, fever and pain. 5-Lipoxygenase (5-LO) initiates the synthesis of leukotrienes (LTs), which are pro-inflammatory mediators. CAY10589 is a dual inhibitor of mPGES-1 (IC50 = 1.3 μM) and 5-LO (IC50 = 1.0 μM). It effectively inhibits PGE2 and LT synthesis in both cell free and intact cell assays. CAY10589 has minor effects on COX-1 and COX-2, inhibiting these enzymes 34% and 38.8%, respectively, at 10 μM. | | Definition | ChEBI: CAY10589 is a member of biphenyls. |
| | CAY10589 Preparation Products And Raw materials |
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