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JZL 195

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JZL 195 Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:JZL195
CAS:1210004-12-8
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G
Company Name: career henan chemical co
Tel: +86-0371-86658258 +8613203830695
Email: factory@coreychem.com
Products Intro: Product Name:JZL 195
CAS:1210004-12-8
Purity:97%-99.9% Package:1KG;1USD
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:JZL195
CAS:1210004-12-8
Purity:99.78% Package:10 mg；100 mg；25 mg；5 mg；50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Zhejiang J&C Biological Technology Co.,Limited
Tel: +1-2135480471 +1-2135480471
Email: sales@sarms4muscle.com
Products Intro: Product Name:JZL-195
CAS:1210004-12-8
Purity:99% Package:5KG;1KG Remarks:JZL-195
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105
Email: sales@invivochem.cn
Products Intro: Product Name:JZL195
CAS:1210004-12-8
Purity:98% Package:5mg Remarks:V2822

JZL 195 manufacturers

  • JZL 195
  • JZL 195 pictures
  • $1.00 / 1KG
  • 2020-03-06
  • CAS:1210004-12-8
  • Min. Order: 1KG
  • Purity: 97%-99.9%
  • Supply Ability: 100kg
JZL 195 Basic information
Product Name:JZL 195
Synonyms:JZL 195;4-nitrophenyl 4-(3-phenoxybenzyl)piperazine-1-carboxylate;4-[(3-Phenoxyphenyl)methyl]-1-piperazinecarboxylic acid 4-nitrophenyl ester;CS-1586;JZL-195;JZL 195;JZL195;1-Piperazinecarboxylic acid, 4-[(3-phenoxyphenyl)methyl]-, 4-nitrophenyl ester;4-Nitrophenyl 4-[(3-phenoxyphenyl)methyl]-1-piperazinecarboxylate;Autophagy,Monoacylglycerol lipase,inhibit,MAGL,Fatty acid amide hydrolase,JZL-195,JZL195,Inhibitor,FAAH,JZL 195
CAS:1210004-12-8
MF:C24H23N3O5
MW:433.46
EINECS:
Product Categories:Inhibitors;API
Mol File:1210004-12-8.mol
JZL 195 Structure
JZL 195 Chemical Properties
Boiling point 581.8±50.0 °C(Predicted)
density 1.303±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Store in freezer, under -20°C
solubility DMSO: ≥5mg/mL at warmed
pka6.13±0.10(Predicted)
form powder
color white to beige
Safety Information
Hazard Codes N
Risk Statements 50
Safety Statements 61
RIDADR UN 3077 9 / PGIII
WGK Germany 3
MSDS Information
JZL 195 Usage And Synthesis
DescriptionFatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) mediate the hydrolysis of the endocannabinoids arachidonoyl ethanolamide (AEA) and 2-arachidonoylglycerol (2-AG), respectively. JZL 195 is a potent inhibitor of both FAAH and MAGL (IC50s = 2 and 4 nM, respectively). It poorly inhibits neuropathy target esterase and ABHD6 and does not inhibit other brain serine hydrolases. JZL 195 displays time-dependent inhibition of FAAH and MAGL in vivo, consistent with a covalent mechanism of activation. The in vivo inhibitory actions of JZL 195 against FAAH and MAGL are comparable to those of the selective inhibitors PF-3845 and JZL 184 , respectively. Through its inhibitory actions, JZL 195 simultaneously augments brain levels of AEA and 2-AG, producing antinociceptive, cataleptic, and hypomotility effects like those produced by direct CB1 agonists.
UsesJZL195 is a selective and efficacious dual FAAH/MAGL inhibitor with IC50 of 13 nM and 19 nM for mouse brain FAAH and MAGL respectively.
storageStore at -20°C
JZL 195 Preparation Products And Raw materials
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