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AdooQ BioScience, LLC
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+1 (866) 930-6790 |
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Product Name:Caspase-3/7 Inhibitor I
CAS:220509-74-0
Purity:98% Package:5mg;10mg;25mg;50mg;100mg;250mg;500mg;1g
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| Company Name: |
ApexBio Technology LLC
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+1-832-696-8203 |
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info@apexbt.com |
| Products Intro: |
Product Name:Caspase-3/7 Inhibitor I
CAS:220509-74-0
Package:1Mg
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| Company Name: |
MQ (shanghai) Pharmaceuticals Co., Ltd.
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13761635123 |
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Product Name:5-[(2S)-2-(METHOXYMETHYL)PYRROLIDIN-1-YL]SULFONYL-1H-INDOLE-2;3-DIONE
CAS:220509-74-0
Purity:98%+ Package:10g,25g,100g,1kg
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| Company Name: |
Shanghai Amico Chemicals Co. LTD
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18019252918 |
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| Products Intro: |
Product Name:5-{[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonyl}-2,3-dihydro-1H-indole-2,3-dione
CAS:220509-74-0
Purity:97% Package:1g,100g,1kg
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| | Caspase-3/7 Inhibitor I Basic information |
| Product Name: | Caspase-3/7 Inhibitor I | | Synonyms: | Pyrrolidine,1-[(2,3-dihydro-2,3-dioxo-1H-indol-5-yl)sulfonyl]-2-(MethoxyMethyl)-,(2S)-;MMPSI, Caspase-3/7 Inhibitor I;(S)-Caspase-3/7 Inhibitor I;5-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonyl-1H-indole-2;5-[(2S)-2-(METHOXYMETHYL)PYRROLIDIN-1-YL]SULFONYL-1H-INDOLE-2;3-DIONE;1H-Indole-2,3-dione, 5-[[(2S)-2-(methoxymethyl)-1-pyrrolidinyl]sulfonyl]-;abs814634;5-{[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonyl}-2,3-dihydro-1H-indole-2,3-dione | | CAS: | 220509-74-0 | | MF: | C14H16N2O5S | | MW: | 324.35 | | EINECS: | | | Product Categories: | Inhibitor | | Mol File: | 220509-74-0.mol |  |
| | Caspase-3/7 Inhibitor I Chemical Properties |
| density | 1.415±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | insoluble in H2O; ≥16.2 mg/mL in DMSO; ≥2.17 mg/mL in EtOH with gentle warming and ultrasonic | | form | solid | | pka | 8.66±0.20(Predicted) | | color | Light yellow to yellow |
| | Caspase-3/7 Inhibitor I Usage And Synthesis |
| Biological Activity | caspase-3/7 inbibitor i is a potent, reversible, isatin sulfonamide-based inhibitor of caspase-3 (ki(app) = 60 nm) and caspase-7 (ki(app) = 170 nm). is a weaker inhibitor of caspase-9 (ki(app) = 3.1 mm). it has only a trivial effect (ki(app) >25 mm) on the activities of caspase-1, caspase-2, caspase-4, caspase-6, and caspase-8. it has been shown to inhibit apoptosis in camptothecin treated jurkat cells (ic50 ~50 μm). also it has been reported to inhibit apoptosis in chondrocytes (44% inhibition at 10 μm and 98% inhibition at 50 μm). selectivity for caspases-3 and 7 involves unique hydrophobic residues in the s2 pocket surrounding the catalytic cysteine residue. [1] [2] in some systems inhibition of caspases-3 and -7 can prevent apoptosis and may therefore have important therapeutic implications. [3]a potent, cell-permeable, and specific, reversible inhibitor of caspase-3 (ki = 60 nm) and caspase-7 (ki = 170 nm). | | target | Caspase-3 | | references | 1. lee, d., et al. 2001. j. med. chem. 44, 2015. 2. lee, d., et al. 2000. j. biol. chem. 275, 16007. 3. clements, k. m., burton‐wurster, n., nuttall, m. e., & lust, g. (2005). caspase‐3/7 inhibition alters cell morphology in mitomycin‐c treated chondrocytes. journal of cellular physiology, 205(1), 133-140. |
| | Caspase-3/7 Inhibitor I Preparation Products And Raw materials |
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