DerMorphin Trifluoroacetate
| 中文名称 | DerMorphin Trifluoroacetate |
|---|---|
| 中文同义词 | 皮啡肽三氟乙酸盐;化合物DERMORPHIN TFA |
| 英文名称 | DerMorphin Trifluoroacetate |
| 英文同义词 | DerMorphin Trifluoroacetic Acid Salt;DerMorphin Trifluoroacetate;Dermorphin TFA;MOR,nerve,spinal,wide-dynamic,neuron,ganglion,neuropathic,heptapeptide,inhibit,nervous,pain,Natural,Dermorphin,opioid,Opioid Receptor,skin,system,peripheral,mu-opioid,Dermorphin TFA,Inhibitor,ligation,amphibian |
| CAS号 | 78331-26-7 |
| 分子式 | C42H51F3N8O12 |
| 分子量 | 916.91 |
| EINECS号 | |
| 相关类别 | Amino Acids & Derivatives;Neurochemicals;Peptides;Amino Acids & Derivatives, Neurochemicals, Peptides |
| Mol文件 | 78331-26-7.mol |
| 结构式 |  |
DerMorphin Trifluoroacetate 性质
| 熔点 | 157-162°C |
|---|---|
| 储存条件 | -20°C Freezer |
| 溶解度 | 可溶于DMSO（少许）、甲醇（少许） |
| 形态 | 固体 |
| 颜色 | 白色 |
Dermorphin TFA 是在两栖类皮肤中发现的一种天然七肽 μ-阿片受体 (MOR) 激动剂。Dermorphin 可用于抑制神经痛。
μ-opioid receptor (MOR)
Dermorphin, a peptide isolated from the skin of Phyllomedusa frogs and the peptide receptor (NOP) component by the endogenous agonist nociceptin/orphanin FQ (N/OFQ). In displacement binding studies at CHO hMu , Dermorphin and DeNo displac the binding of [ 3 H]-DPN in a concentration dependent and saturable manner. Dermorphin displays an affinity of 7.17, while N/OFQ fails to displace [ 3 H]-DPN at the Delta receptor. Dermorphin and DeNo stimulate the binding of GTPγ[ 35 S] in a concentration dependent and saturable manner at the Mu receptor.