131359-24-5
| 中文名称 | 131359-24-5 |
|---|---|
| 中文同义词 | (E,E)-二(2-羟基苄亚基)丙酮;化合物2-HBA;2-HBA8 |
| 英文名称 | (E,E)-Bis(2-hydroxybenzylidene)acetone (2-HBA) |
| 英文同义词 | (E,E)-Bis(2-hydroxybenzylidene)acetone (2-HBA);(1E,4E)-1,5-Bis(2-Hydroxyphenyl)-1,4-pentadien-3-one;HBB2;2-HBA;(E,E)-Bis(2-hydroxybenzylidene)acetone\n(2-HBA);2-HBA Exclusive;bis(2-hydroxybenzylidene)acetone;1,4-Pentadien-3-one, 1,5-bis(2-hydroxyphenyl)-, (1E,4E)- |
| CAS号 | 131359-24-5 |
| 分子式 | C17H14O3 |
| 分子量 | 266.29 |
| EINECS号 | |
| 相关类别 | 抑制剂;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals |
| Mol文件 | 131359-24-5.mol |
| 结构式 |  |
131359-24-5 性质
| 储存条件 | Sealed in dry,Store in freezer, under -20°C |
|---|---|
| 溶解度 | 在DMSO中的溶解度为15mg/mL（澄清溶液） |
| 形态 | 粉末 |
| 颜色 | 白色至米色 |
| InChIKey | YNVAHBUBGBLIEY-WGDLNXRISA-N |
2-HBA 是一个有效的 NAD(P)H: 醌受体氧化还原酶 1 (NQO1) 诱导剂，也可以激活半胱天冬酶-3 (caspase-3) 和半胱天冬酶-10 (caspase-10)。
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Caspase-3
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Caspase-10
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When L1210 cells are exposed to 0.6 μM 2-HBA (bis(2-hydroxy-benzylidene)acetone), the specific activities of NQO1 and glutathione reductase increase by 6- and 1.5-fold, respectively. The total cellular glutathione content is also coordinately induced by 2.4-fold. In a more detailed study it is found that NQO1 is induced by 2-HBA in a concentration-dependent manner. Treatments with 2-HBA cause cell cycle arrest and apoptosis in both L1210 wild type cells and their Y8 drug-resistant counterparts in a concentration-dependent manner. 2-HBA can also activate caspase-3 and caspase-10.
安全信息
| WGK Germany | 3 |
|---|
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/08/19 | HY-103667 | 131359-24-5 2-HBA | 131359-24-5 | 5mg | 600元 |
| 2024/08/19 | HY-103667 | 131359-24-5 2-HBA | 131359-24-5 | 10mM * 1mLin DMSO | 660元 |