131359-24-5
中文名称 | 131359-24-5 |
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中文同义词 | (E,E)-二(2-羟基苄亚基)丙酮;化合物2-HBA;2-HBA8 |
英文名称 | (E,E)-Bis(2-hydroxybenzylidene)acetone (2-HBA) |
英文同义词 | (E,E)-Bis(2-hydroxybenzylidene)acetone (2-HBA);(1E,4E)-1,5-Bis(2-Hydroxyphenyl)-1,4-pentadien-3-one;HBB2;2-HBA;(E,E)-Bis(2-hydroxybenzylidene)acetone\n(2-HBA);2-HBA Exclusive;bis(2-hydroxybenzylidene)acetone;1,4-Pentadien-3-one, 1,5-bis(2-hydroxyphenyl)-, (1E,4E)- |
CAS号 | 131359-24-5 |
分子式 | C17H14O3 |
分子量 | 266.29 |
EINECS号 | |
相关类别 | 抑制剂;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals |
Mol文件 | 131359-24-5.mol |
结构式 | ![]() |
131359-24-5 性质
储存条件 | Sealed in dry,Store in freezer, under -20°C |
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溶解度 | 在DMSO中的溶解度为15mg/mL(澄清溶液) |
形态 | 粉末 |
颜色 | 白色至米色 |
InChIKey | YNVAHBUBGBLIEY-WGDLNXRISA-N |
Caspase-3
|
Caspase-10
|
When L1210 cells are exposed to 0.6 μM 2-HBA (bis(2-hydroxy-benzylidene)acetone), the specific activities of NQO1 and glutathione reductase increase by 6- and 1.5-fold, respectively. The total cellular glutathione content is also coordinately induced by 2.4-fold. In a more detailed study it is found that NQO1 is induced by 2-HBA in a concentration-dependent manner. Treatments with 2-HBA cause cell cycle arrest and apoptosis in both L1210 wild type cells and their Y8 drug-resistant counterparts in a concentration-dependent manner. 2-HBA can also activate caspase-3 and caspase-10.
安全信息
WGK Germany | 3 |
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-103667 | 131359-24-5 2-HBA | 131359-24-5 | 5mg | 600元 |
2024/08/19 | HY-103667 | 131359-24-5 2-HBA | 131359-24-5 | 10mM * 1mLin DMSO | 660元 |