R 112 (pharMaceutical)

R 112 (pharMaceutical) Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:R112
CAS:575474-82-7
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G
Company Name: Zhejiang J&C Biological Technology Co.,Limited
Tel: +1-2135480471 +1-2135480471
Email: sales@sarms4muscle.com
Products Intro: Product Name:R112
CAS:575474-82-7
Purity:99% Package:5KG;1KG Remarks:R112
Company Name: Henan Alfa Chemical Co., Ltd
Tel: +8618339805032
Email: alfa4@alfachem.cn
Products Intro: CAS:575474-82-7
Purity:97%+ Package:5g; 25g; 100g; 500g; 1kg; 25kg
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105
Email: sales@invivochem.cn
Products Intro: Product Name:R112
CAS:575474-82-7
Purity:98% Package:5mg Remarks:V5244
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354
Email: support@targetmol.com
Products Intro: Product Name:R112;(E)-Elafibranor
CAS:575474-82-7
Package:1 mg;1 mL * 10mM (in DMSO);10 mg;100 mg;2 mg;25 mg;5 mg;50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
R 112 (pharMaceutical) Basic information
Product Name:R 112 (pharMaceutical)
Synonyms:R 112 (pharMaceutical);Phenol, 3,3'-[(5-fluoro-2,4-pyrimidinediyl)diimino]bis-;(E)-Elafibranor;3,3'-[(5-Fluoro-2,4-pyrimidinediyl)diimino]diphenol;R-112; R 112;R112, >98%;Spleen tyrosine kinase,allergic rhinitis,R112,fast,tryptase,Inhibitor,R 112,phosphorylation,IL-8,GM-CSF,histamine,LTC4,reversible,basophil,R-112,TNF-α,Syk,inhibit;3,3'-((5-Fluoropyrimidine-2,4-diyl)bis(azanediyl))diphenol
CAS:575474-82-7
MF:C16H13FN4O2
MW:312.3
EINECS:
Product Categories:
Mol File:575474-82-7.mol
R 112 (pharMaceutical) Structure
R 112 (pharMaceutical) Chemical Properties
Boiling point 552.0±60.0 °C(Predicted)
density 1.494±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO:30.0(Max Conc. mg/mL);96.1(Max Conc. mM)
form A crystalline solid
pka9.48±0.10(Predicted)
color Light yellow to yellow
Safety Information
MSDS Information
R 112 (pharMaceutical) Usage And Synthesis
DescriptionR112 is an inhibitor of spleen tyrosine kinase (Syk; IC50 = 226 nM in cultured human mast cells) that acts in an ATP-competitive and reversible manner (Ki = 96 nM). It inhibits mast cell and basophil degranulation induced by anti-IgE cross-linking (EC50s = 353 and 280 nM, respectively). It also inhibits basophil degranulation induced by an allergen with an EC50 value of 490 nM. R112 inhibits the production of leukotriene C4 (LTC4; ) and decreases cytokine levels in cultured human mast cells.
UsesR 112 is Syk inhibitor. It can be used in biological study and therapeutic use of application of cultured human mast cells (CHMC) for design and structure-activity relationship of IgE-mediated mast cell activation inhibitors.
R 112 (pharMaceutical) Preparation Products And Raw materials
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