9H-Purin-6-aMine, 9-(1-Methylethyl)-N-[[3-(trifluoroMethyl)phenyl]Methyl]- manufacturers
- Longdaysin
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- $43.00 / 5mg
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2024-11-17
- CAS:1353867-91-0
- Min. Order:
- Purity: 99.97%
- Supply Ability: 10g
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| | 9H-Purin-6-aMine, 9-(1-Methylethyl)-N-[[3-(trifluoroMethyl)phenyl]Methyl]- Basic information |
| Product Name: | 9H-Purin-6-aMine, 9-(1-Methylethyl)-N-[[3-(trifluoroMethyl)phenyl]Methyl]- | | Synonyms: | 9H-Purin-6-aMine, 9-(1-Methylethyl)-N-[[3-(trifluoroMethyl)phenyl]Methyl]-;9-propan-2-yl-N-[[3-(trifluoromethyl)phenyl]methyl]purin-6-amine;Reaxys ID: 25796871;ERK,Cyclin dependent kinase,inhibit,CDK,Inhibitor,Longdaysin,Casein Kinase,Extracellular signal regulated kinases;Longdaysin, 10 mM in DMSO | | CAS: | 1353867-91-0 | | MF: | C16H16F3N5 | | MW: | 335.33 | | EINECS: | 604-604-1 | | Product Categories: | | | Mol File: | 1353867-91-0.mol | ![9H-Purin-6-aMine, 9-(1-Methylethyl)-N-[[3-(trifluoroMethyl)phenyl]Methyl]- Structure](CAS/20150408/GIF/1353867-91-0.gif) |
| | 9H-Purin-6-aMine, 9-(1-Methylethyl)-N-[[3-(trifluoroMethyl)phenyl]Methyl]- Chemical Properties |
| Boiling point | 447.6±55.0 °C(Predicted) | | density | 1.35±0.1 g/cm3(Predicted) | | storage temp. | 4°C, protect from light | | solubility | DMSO : 125 mg/mL (372.77 mM);Water : < 0.1 mg/mL (insoluble) | | pka | 3.42±0.10(Predicted) | | form | Solid | | color | White to off-white |
| | 9H-Purin-6-aMine, 9-(1-Methylethyl)-N-[[3-(trifluoroMethyl)phenyl]Methyl]- Usage And Synthesis |
| Uses | Longdaysin may be used to study cell signaling th at regulate the circadian clock and behavior. | | Biological Activity | Longdaysin inhibits CK1, ERK2, and CDK7 kinases in low mM concentrations. The activity of longdaysin results in a lengthening of circadian periods in cell based and in vivo systems. Transgenic zebrafish harboring a per3-luc reporter gene displayed a 10 hour lengthening of circadian period when treated with longdaysin. Longdaysin reduces the phosphorylation of PER1 the regulator of molecular clock function and manipulates the circadian clock. | | in vivo | Longdaysin (0-9 μM; 1 week) increases circadian period in zebrafish[2].
Longdaysin (5 mg/kg, i.p., every 3 days for 3 weeks) inhibits tumor growth in MDA-MB-231 xenografts mice[3].
| Animal Model: | MDA-MB-231 xenografts[3] | | Dosage: | 5 mg/kg | | Administration: | i.p., every 3 days for 3 weeks | | Result: | Decreased tumor cell density and proliferation (indicated by Ki-67).
Reduced the expression of active and total β-catenin, and decreased the expression of phosphorylated and total LRP6, phosphorylated DVL2, and active and total β-catenin.
Reduced mRNA expression of the Wnt target genes including Axin2, DKK1, LEF1, and Survivin.
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| | IC 50 | CKIα: 5.6 μM (IC50); CKIδ: 8.8 μM (IC50); CDK7: 29 μM (IC50); ERK2: 52 μM (IC50) |
| | 9H-Purin-6-aMine, 9-(1-Methylethyl)-N-[[3-(trifluoroMethyl)phenyl]Methyl]- Preparation Products And Raw materials |
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