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AdooQ BioScience, LLC
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Product Name:FM19G11
CAS:329932-55-0
Purity:98% Package:5mg;10mg;25mg;50mg;100mg;250mg;500mg;1g
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| Company Name: |
Sigma-Aldrich
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021-61415566 800-8193336 |
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| Products Intro: |
Product Name:FM19G11
CAS:329932-55-0
Purity:>=98% (HPLC) Package:25MG Remarks:F8807-25MG
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| | HIF-1alpha/2alpha Inhibitor Basic information |
| Product Name: | HIF-1alpha/2alpha Inhibitor | | Synonyms: | FM19G11;HIF-1alpha/2alpha Inhibitor;[2-oxo-2-(p-tolyl)ethyl] 3-[(2,4-dinitrobenzoyl)amino]benzoate;3-[(2,4-Dinitrobenzoyl)amino]-benzoic acid 2-(4-methylphenyl)-2-oxoethyl ester;HIF-1α/2α Inhibitor IV, FM19G11;2-Oxo-2-(p-tolyl)ethyl 3-(2,4-dinitrobenzamido)benzoate;FM 19G11 NEW;Benzoic acid, 3-[(2,4-dinitrobenzoyl)amino]-, 2-(4-methylphenyl)-2-oxoethyl ester | | CAS: | 329932-55-0 | | MF: | C23H17N3O8 | | MW: | 463.4 | | EINECS: | | | Product Categories: | | | Mol File: | 329932-55-0.mol |  |
| | HIF-1alpha/2alpha Inhibitor Chemical Properties |
| storage temp. | 2-8°C | | solubility | DMSO: ≥40mg/mL | | form | powder | | color | off-white to light brown |
| | HIF-1alpha/2alpha Inhibitor Usage And Synthesis |
| Uses | FM19G11 has been used as ahypoxia-inducible factor-1α (HIF- 1α):
- to study the effects ofFM19G11-loaded gold nanoparticles (NPs) on self-renewal and proliferation of ependymal stem progenitor cells (epSPCs) of mice
- to study its effects on the O6-methylguanine DNA-methyltransferase (MGMT) expression in glioblastoma (GBM) cells
- to study its effects on microphthalmia-associated transcription factor (MITF) expression in melanoma cell line
| | Definition | ChEBI: 3-[[(2,4-dinitrophenyl)-oxomethyl]amino]benzoic acid [2-(4-methylphenyl)-2-oxoethyl] ester is a member of benzamides. | | Biochem/physiol Actions | FM19G11 is an inhibitor of Hypoxia Inducible Factors α (HIFα), reported to affect self-renewal and differentiation of stem cells. Hypoxia-inducible factors (HIFs) are transcription factors that respond to changes in available oxygen in the cellular environment. Among other functions (like angiogenesis), HIFα proteins affect the self-renewal and the differentiation processes of stem cells. FM19G11 inhibits the HIFα proteins that repress the target genes of the two α subunits, in various tumor cell lines as well as in adult and embryonic stem cell (ESC) models. | | storage | Store at +4°C |
| | HIF-1alpha/2alpha Inhibitor Preparation Products And Raw materials |
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