| Company Name: |
J & K SCIENTIFIC LTD.
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| Tel: |
010-82848833 400-666-7788 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:EMPA
CAS:680590-49-2
Package:100Mg,10Mg,50Mg
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| Product Name: | EMPA | | Synonyms: | N-Ethyl-2-[(6-methoxy-3-pyridinyl)[(2-methylphenyl)sulfonyl]amino]-N-(3-pyridinylmethyl)-acetamide;N-ETHYL-2-[(6-METHOXYPYRIDIN-3-YL)-(2-METHYLPHENYL)SULFONYLAMINO]-N-(PYRIDIN-3-YLMETHYL)ACETAMIDE;EMPA, CID 9981404;Acetamide, N-ethyl-2-[(6-methoxy-3-pyridinyl)[(2-methylphenyl)sulfonyl]amino]-N-(3-pyridinylmethyl)-;Hypocretin Receptor,EMPA,Orexin Receptor (OX Receptor),HCRT Receptor,inhibit,Inhibitor | | CAS: | 680590-49-2 | | MF: | C23H26N4O4S | | MW: | 454.54 | | EINECS: | | | Product Categories: | Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds | | Mol File: | 680590-49-2.mol |  |
| Boiling point | 660.7±65.0 °C(Predicted) | | density | 1.280±0.06 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | Soluble to 100 mM in DMSO and to 100 mM in ethanol | | form | Powder | | pka | 4.77±0.10(Predicted) | | color | white to light brown |
| Hazard Codes | Xn | | Risk Statements | 22 | | WGK Germany | 3 |
| Description | EMPA is an orexin 2 receptor (OX2R) antagonist (Ki = 1.1 nM). It is selective for OX2R over OX1R (Ki = 900 nM). EMPA inhibits orexin-A- and orexin-B-induced calcium mobilization (IC50s = 8.8 and 7.9 nM, respectively) and increases orexin-A- and orexin-B-induced inositol phosphate accumulation (EC50s = 1.1 and 2.4 nM, respectively) in CHO(dHFr-) cells expressing recombinant human OX2R. It reduces spontaneous locomotor activity and orexin-B-induced hyperlocomotion in mice when administered at doses ranging between 10 and 300 mg/kg. | | Uses | EMPA is a novel high-affinity, selective antagonist for the OX2 receptor. | | storage | Store at -20°C |
| | EMPA Preparation Products And Raw materials |
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