MONOMETHYLAURISTATIN F HYDROCHLORIDE
中文名称 | MONOMETHYLAURISTATIN F HYDROCHLORIDE |
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中文同义词 | 细胞分裂抑制剂(MMAF HYDROCHLORIDE);化合物 T16121 |
英文名称 | MMAF (Hydrochloride) |
英文同义词 | MMAF (Hydrochloride);Monomethylauristatin F Hydrochloride;MMAF HCl;CS-1270;((2R,3R)-3-((S)-1-((3R,4S,5S)-4-((S)-N,3-dimethyl-2-((S)-3-methyl-2-(methylamino)butanamido)butanamido)-3-methoxy-5-methylheptanoyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanoyl)-L-phenylalanine hydrochloride |
CAS号 | 1415246-68-2 |
分子式 | C39H66ClN5O8 |
分子量 | 768.43 |
EINECS号 | |
相关类别 | 细胞生物学试剂 |
Mol文件 | 1415246-68-2.mol |
结构式 | ![]() |
MONOMETHYLAURISTATIN F HYDROCHLORIDE 性质
储存条件 | Store at -20°C,unstable in solution, ready to use. |
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溶解度 | DMSO:27 mg/mL(35.14 mM 和升温) |
形态 | 固体 |
颜色 | 白色至米白色 |
Auristatin
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MMAF inhibits anaplastic large cell lymphoma Karpas 299, breast carcinoma H3396, renal cell carcinoma 786-O and Caki-1 cells with IC 50 s of 119, 105, 257 and 200 nM in vitro cytotoxicity assay.
The maximum tolerated dose in mice of MMAF (>16 mg/kg) is much higher than MMAE (1 mg/kg). cAC10-L1-MMAF 4 has an MTD of 50 mg/kg in mice and 15 mg/kg in rats. The corresponding cAC10-L4-MMAF 4 ADC was much less toxic, having MTDs in mice and rats of >150 mg/ kg and 90 mg/kg in rats, respectively.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-15579A | MONOMETHYLAURISTATIN F HYDROCHLORIDE MMAF hydrochloride | 1415246-68-2 | 5mg | 400元 |
2024/08/19 | HY-15579A | MONOMETHYLAURISTATIN F HYDROCHLORIDE MMAF hydrochloride | 1415246-68-2 | 10mg | 560元 |