| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:PF-05139962
CAS:1393712-18-9
Purity:0 Package:25mg/RMB 10600;100mg/RMB 17500;50mg/RMB 13800
|
|
| | PF-05139962 Basic information |
| Product Name: | PF-05139962 | | Synonyms: | PF-05139962;Urea, N-[4-[7,8-dihydro-4-[(3S)-3-methyl-4-morpholinyl]-6,6-dioxido-5H-thiopyrano[4,3-d]pyrimidin-2-yl]phenyl]-N'-ethyl- | | CAS: | 1393712-18-9 | | MF: | C21H27N5O4S | | MW: | 445.54 | | EINECS: | | | Product Categories: | | | Mol File: | 1393712-18-9.mol |  |
| | PF-05139962 Chemical Properties |
| Boiling point | 629.5±55.0 °C(Predicted) | | density | 1.324±0.06 g/cm3(Predicted) | | pka | 13.81±0.46(Predicted) |
| | PF-05139962 Usage And Synthesis |
| Description | PF-05139962 is a novel potent mTOR inhibitor with excellent mTOR biochemical inhibition, cellular potency, kinase selectivity and in vitro ADME properties. PF-05139962 has pS473 and pS6 cellular IC50 = 48 and 6 nM respectively. PF-05139962 has great selectivity against other receptors and kinases. No genotoxicity was observed on this compound and no more than 25% inhibiton was observed for major CYP enzymes (3A4, 1A2, 2C9, 2D6) at 3 uM. This compound has LE = 0.35 and LipE up to 6.8 which is in a very desirable range for a kinase inhibitor. |
| | PF-05139962 Preparation Products And Raw materials |
|