Log in | Join Free | china | japan | germany

SQ 22,536

Request For Quotation
SQ 22,536 Suppliers list
Company Name: Capot Chemical Co.,Ltd.
Tel: 571-85586718 +8613336195806
Email: sales@capotchem.com
Products Intro: Product Name:9-(Tetrahydrofuran-2-yl)-9H-purin-6-amine
CAS:17318-31-9
Purity:98%(Min,HPLC) Package:100g;1kg;5kg,10kg,25kg,50kg
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:SQ22536
CAS:17318-31-9
Purity:98% HPLC Package:5MG;10MG;50MG;100MG,1G,5G
Company Name: Alchem Pharmtech,Inc.
Tel: 8485655694
Email: sales@alchempharmtech.com
Products Intro: Product Name:9-(Tetrahydrofuran-2-yl)-9H-purin-6-amine
CAS:17318-31-9
Purity:97+% Package:1g;10g;100g;;1kg Remarks:Z-36538
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:SQ22536；SQ 22536;9-(tetrahydrofuran-2-yl)-9h-purin-6-amine
CAS:17318-31-9
Purity:98.80% Package:1 mL * 10mM (in DMSO)；10 mg；100 mg；200 mg；25 mg；5 mg；50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel: 86-571-88216897,88216896 13588875226
Email: sales@hzclap.com
Products Intro: Product Name:SQ-22536
CAS:17318-31-9
Purity:99% Package:10kg 25kg 200 kilograms per barrel Remarks:good
SQ 22,536 Basic information
Product Name:SQ 22,536
Synonyms:9-(2-tetrahydrofuryl)adenine;SQ 22,536 ADENYLATE CYCLASE INH;9-(Tetrahydro-2-furynal)-9H-purin-6-amine;SQ22,536/Inhibitor;9-(Tetrahydro-2-furanyl)-9H-purin-6-amine, 9-THF-Ade;6-Amino-9-[(tetrahydrofuran)-2-yl]-9H-purine;9-(Tetrahydrofuran-2-yl)-9H-purine-6-amine;6-Amino-9-(tetrahydro-2-furyl)-9H-purine
CAS:17318-31-9
MF:C9H11N5O
MW:205.22
EINECS:633-987-7
Product Categories:
Mol File:17318-31-9.mol
SQ 22,536 Structure
SQ 22,536 Chemical Properties
Melting point 160-161℃
Boiling point 474.8±55.0 °C(Predicted)
density 1.70±0.1 g/cm3(Predicted)
storage temp. Keep in dark place,Inert atmosphere,2-8°C
solubility H2O: 21 mg/mL
form solid
pka3.82±0.10(Predicted)
color white to off-white
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
WGK Germany 3
HS Code 2934.99.9001
MSDS Information
ProviderLanguage
SigmaAldrich English
SQ 22,536 Usage And Synthesis
DescriptionSQ 22,536 is an inhibitor of adenylyl cyclase with an IC50 value of 13 μM for inhibition of prostaglandin E1-stimulated increase in cAMP in intact platelets. It has been used to evaluate adenylyl cyclase activity during iloprost-induced vasorelaxation of isolated pulmonary veins or aorta in several research paradigms, inhibiting cAMP elevation at concentrations of 100-300 μM without effecting relaxation.
UsesSQ 22,536 was used to study the role of adenylate cyclase in differentiation of PC12 cells and in gap junctional intercellular communication in breast cancer cells.
DefinitionChEBI: A nucleoside analogue that is adenine in which the nitrogen at position 9 has been substituted by a tetrahydrofuran-2-yl group. It is an adenylate cyclase inhibitor.
Biological ActivityInhibitor of adenylyl cyclase (IC 50 = 1.4 μ M). Inhibits PGE 1 -stimulated increases in cAMP levels in intact human platelets.
Biochem/physiol ActionsSQ 22,536 is an effective inhibitor of not only basal but also prosptaglandin E1-activated adenylate cyclase activities in platelets.1 It reverses hyperalgesia contralaterally and ipsilaterally when injected intramuscularly in rats.2
storageStore at +4°C
SQ 22,536 Preparation Products And Raw materials
Tag:SQ 22,536(17318-31-9) Related Product Information
Cyclic AMP 5'-IODO-5'-DEOXYADENOSINE ADENOSINE-2':3'-CYCLIC MONOPHOSPHATE, SODIUM SALT 2'-Deoxyadenosine monohydrate 8-BROMOADENOSINE 3'-ADENYLIC ACID N6-ISOPENTENYLADENOSINE-D6 2',3'-O-Isopropylideneadenosine 5'-Tosyladenosine 2-Chloroadenosine 2'-Deoxyadenosine 5'-phosphate Vidarabine Adenosine 5'-monophosphate monohydrate Bucladesine sodium N6-BENZYLADENOSINE N6-Benzoyl-2'-deoxyadenosine 6-METHYLAMINOPURINE 9-RIBOFURANOSIDE 5'-ACETYL-2',3'-ISOPROPYLIDENEADENOSINE