6-CYANO-7-NITROQUINOXALINE-2;3-DIONE DISODIUM
| 中文名称 | 6-CYANO-7-NITROQUINOXALINE-2;3-DIONE DISODIUM |
|---|---|
| 中文同义词 | CNQX二钠盐;7-硝基-2,3-二氧代-1,2,3,4-四氢喹喔啉-6-甲腈二钠盐;CNQX二钠 |
| 英文名称 | CNQX disodium salt |
| 英文同义词 | 3-dione disodium;6-Cyano-7-nitroquinoxaline-2;7-Nitro-2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-carbonitrile, disodium salt |
| CAS号 | 479347-85-8 |
| 分子式 | C9H5N4NaO4 |
| 分子量 | 256.15 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 479347-85-8.mol |
| 结构式 |  |
6-CYANO-7-NITROQUINOXALINE-2;3-DIONE DISODIUM 性质
| 储存条件 | Desiccate at RT |
|---|---|
| 溶解度 | DMSO 中≥27.6 mg/mL；不溶于乙醇；不溶于水 |
| 形态 | 固体 |
| 颜色 | 棕色或黄色 |
| 水溶解性 | Soluble to 20 mM in water |
IC50: 0.3 μM (AMPA) and 1.5 μM (kainate receptor)
CNQX disodium (FG9065 disodium; 2-5 μM) reversibly blocks the Schaffer collateral and mossy fibre excitatory postsynaptic potential (EPSP), while sparing the fast and slow GABA-mediated inhibition in superfusion of hippocampal slices.
CNQX disodium (1-5 μM) produces a selective and dose-dependent reduction in the amplitude of the monosynaptic component of the DR-VRR recorded from lumbar spinal segments.
CNQX disodium (FG9065 disodium; 0.75-3 mg/kg; IP; 20 min before testing) decreased the number of cocaine responses in a dose-dependent manner during the first 15-min cocaine-free interval.
The bilateral infusion of CNQX disodium (0.5 or 1.25 μg) into the amygdala or dorsal hippocampus 10 min prior to a retention test partially blocks the expression of stepdown inhibitory avoidance in rats 24 h after training. CNQX disodium causes a complete blockade at a dose of 0.5 μg.
| Animal Model: | Male Wistar rats weighing 180-200 g |
| Dosage: | 0.75, 1.5, and 3 mg/kg |
| Administration: | IP; 20 min before testing |
| Result: | Decreased the number of cocaine (IV; 0.25 mg/infusion) responses in a dose-dependent manner during the first 15-min cocaine-free interval. |