| Company Name: |
Accela ChemBio Inc. |
| Tel: |
+1-858-6993322 |
| Email: |
info@accelachem.com |
| Products Intro: |
Product Name:Sodium (R)-3-[(3R,5S,6R,7R,8S,9S,10S,13R,14S,17R)-6-Ethyl-3,7-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl]butyl Sulfate
CAS:1000403-03-1
Purity:>95% Package:0.25g Remarks:SY416548
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INT-767 manufacturers
- INT-767
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- $399.00 / 1mg
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2024-11-20
- CAS:1000403-03-1
- Min. Order:
- Purity: 98%
- Supply Ability: 10g
- INT-767
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- $399.00 / 1mg
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2024-11-19
- CAS:1000403-03-1
- Min. Order:
- Purity: 98%
- Supply Ability: 10g
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| | INT-767 Basic information |
| Product Name: | INT-767 | | Synonyms: | INT-767;INT-767
(INT767);Sodium (R)-3-[(3R,5S,6R,7R,8S,9S,10S,13R,14S,17R)-6-Ethyl-3,7-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl]butyl Sulfate | | CAS: | 1000403-03-1 | | MF: | C25H45NaO6S | | MW: | 496.68 | | EINECS: | | | Product Categories: | | | Mol File: | 1000403-03-1.mol |  |
| | INT-767 Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMSO : ≥ 205.5 mg/mL (415.44 mM) | | form | Solid | | color | White to off-white |
| | INT-767 Usage And Synthesis |
| Description | INT-767 is a G-protein coupled/Farnesoid X-activated receptor agonist potentially for the treatment of hepatic fibrosis. INT-767 significantly improved serum liver enzymes, hepatic inflammation, and biliary fibrosis in Mdr2(-/-) mice. INT-767 significantly induced bile flow and biliary HCO?3- output, as well as gene expression of carbonic anhydrase 14, an important enzyme able to enhance HCO?3- transport, in an Fxr-dependent manner. In addition, INT-767 dramatically reduced bile acid synthesis via the induction of ileal Fgf15 and hepatic Shp gene expression, thus resulting in significantly reduced biliary bile acid output in Mdr2(-/-) mice. |
| | INT-767 Preparation Products And Raw materials |
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