| Company Name: |
Haoyuan Chemexpress Co., Ltd.
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| Tel: |
021-58950125 |
| Email: |
info@chemexpress.com |
| Products Intro: |
Product Name:INT-767
CAS:1000403-03-1
Purity:>98% Package:3500RMB/2mg
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| | INT-767 Basic information |
| | INT-767 Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMSO : ≥ 205.5 mg/mL (415.44 mM) | | form | Solid | | color | White to off-white |
| | INT-767 Usage And Synthesis |
| Description | INT-767 is a G-protein coupled/Farnesoid X-activated receptor agonist potentially for the treatment of hepatic fibrosis. INT-767 significantly improved serum liver enzymes, hepatic inflammation, and biliary fibrosis in Mdr2(-/-) mice. INT-767 significantly induced bile flow and biliary HCO?3- output, as well as gene expression of carbonic anhydrase 14, an important enzyme able to enhance HCO?3- transport, in an Fxr-dependent manner. In addition, INT-767 dramatically reduced bile acid synthesis via the induction of ileal Fgf15 and hepatic Shp gene expression, thus resulting in significantly reduced biliary bile acid output in Mdr2(-/-) mice. |
| | INT-767 Preparation Products And Raw materials |
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