1883545-52-5
| 中文名称 | 1883545-52-5 |
|---|---|
| 中文同义词 | 化合物MM-102 TFA;MM-102 TFA,WDR5 / MLL相互作用抑制剂;(S)-N-(双(4-氟苯基)甲基)-1-(2-(2-乙基-2-异丁酰氨基丁酰氨基)-5-胍基戊酰氨基)环戊烷-1-甲酰胺 2,2,2-三氟乙酸盐 |
| 英文名称 | MM-102 (trifluoroacetate) |
| 英文同义词 | MM-102 (trifluoroacetate);MM-102 (TFA);HMTASE INHIBITOR IX (TFA);1-[[(2S)-5-[(Aminoiminomethyl)amino]-2-[[2-ethyl-2-[(2-methyl-1-oxopropyl)amino]-1-oxobutyl]amino]-1-oxopentyl]amino]-N-[bis(4-fluorophenyl)methyl]-cyclopentanecarboxamide trifluoroacetate;MM102,HMTase Inhibitor IX,MM-102,MM 102 TFA,MM 102,inhibit,MM102 TFA,Histone Methyltransferase,Inhibitor;(S)-N-(Bis(4-fluorophenyl)methyl)-1-(2-(2-ethyl-2-isobutyramidobutanamido)-5-guanidinopentanamido)cyclopentane-1-carboxamide 2,2,2-trifluoroacetate |
| CAS号 | 1883545-52-5 |
| 分子式 | C37H50F5N7O6 |
| 分子量 | 783.84 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 1883545-52-5.mol |
| 结构式 |  |
1883545-52-5 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | 二甲基亚砜：≥100mg/mL（127.58mM） |
| 形态 | 固体 |
| 颜色 | 白色至米白色 |
IC50: 2.4 nM (MLL).
MM-102 (HMTase Inhibitor IX) inhibits MLL1 methyltransferase activity and MLL-1-induced HoxA9 and Meis-1 gene expression in leukemia cells expressing the MLL1-AF9 fusion gene. Also inhibits cell growth and induces apoptosis in leukemia cells harbouring MLL1 fusion proteins. MM-102 (TFA), with the highest binding affinities to WDR5, also show the most potent inhibitory activity in the HMT assay withIC 50 =0.4-0.9 μM. MM-102 (HMTase Inhibitor IX) dose-dependently inhibits cell growth in the MV4;11 and KOPN8 leukemia cell lines, which carry MLL1-AF4 and MLL1-ENL fusion proteins, respectively. MM-102 (HMTase Inhibitor IX) has IC 50 =25 μM in both cell lines and completely inhibits cell growth in these cell lines at 75 μM. MM-102 (HMTase Inhibitor IX) effectively and selectively inhibits cell growth and induces apoptosis in leukemia cells harboring MLL1 fusion proteins and has minimal effect in leukemia cells with wild-type MLL1 protein.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/11/08 | HY-12220A | 1883545-52-5 MM-102 TFA | 1883545-52-5 | 2mg | 698元 |
| 2024/11/08 | HY-12220A | 1883545-52-5 MM-102 TFA | 1883545-52-5 | 5 mg | 1463元 |