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Nanjing Chemlin Chemical Co., Ltd
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Product Name:9H-Pyrido[3,4-b]indol-1-carboxylic acid
CAS:26052-96-0
Purity:98% Package:5KG; 1KG
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BOC Sciences
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Product Name:β-Carboline-1-carboxylic acid
CAS:26052-96-0
Purity:>95% by HPLC Remarks:β-Carboline-1-carboxylic acid is an alkaloid.
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AnEasyTech Shanghai Co., Ltd.
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Product Name:9H-pyrido<3,4-b>indole-1-carboxylic acid
CAS:26052-96-0
Purity:98% Package:25G;100G;500G;1KG;5KG;25KG;100KG;T; 1kg/桶/
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ChemeGen 中国
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Product Name:β-Carboline-1-carboxylic Acid
CAS:26052-96-0
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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Shanghai Haohong Scientific Co., Ltd.
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| Products Intro: |
Product Name:9H-Pyrido[3,4-b]indole-1-carboxylic acid
CAS:26052-96-0
Purity:97%
|
|
| | 9H-Pyrido[3,4-b]indole-1-carboxylic acid
Basic information |
| | 9H-Pyrido[3,4-b]indole-1-carboxylic acid
Chemical Properties |
| Boiling point | 538.7±30.0 °C(Predicted) | | density | 1.497±0.06 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | DMSO: soluble; Methanol: soluble | | form | A solid | | pka | 0.83±0.30(Predicted) |
| | 9H-Pyrido[3,4-b]indole-1-carboxylic acid
Usage And Synthesis |
| Biological Activity | β-Carboline-1-carboxylic acid is an alkaloid that has been found in P. quassioides and has diverse biological activities.1,2,3 It reduces LPS-induced increases in MCP-1, TNF-α, IL-6, and IL-1β levels in RAW 264.7 cells when used at a concentration of 15 μg/ml and inhibits the epithelial-to-mesenchymal transition (EMT) induced by TGF-β1 in A549 cells.2 β-Carboline-1-carboxylic acid induces cytotoxicity in CT26.WT, K562, and SGC-7901 cells (IC50s = 14.96, 22.11, and 19.7 μg/ml, respectively) but not HepG2 or A549 cells (IC50s = 36.41 and 41.51 μg/ml, respectively).1 It also inhibits cAMP phosphodiesterase with an IC50 value of 96 μM.3 | | References | 1.Lai, Z.-Q., Liu, W.-H., Ip, S.-P., et al.Seven alkaloids from Picrasma quassioides and their cytotoxic activitiesChem. Nat. Compd.50(5)884-888(2014)
2.Cui, Y., Jiang, L., Yu, R., et al.β-carboline alkaloids attenuate bleomycin induced pulmonary fibrosis in mice through inhibiting NF-kb/p65 phosphorylation and epithelial-mesenchymal transitionJ. Ethnopharmacol.243112096(2019)
3.Sung, Y.-I., Koike, K., Nikaido, T., et al.Inhibitors of cyclic AMP phosphodiesterase in Picrasma quassioides BENNET, and inhibitory activities of related β-carboline alkaloidsChem. Pharm. Bull. (Tokyo)32(5)1872-1877(1984) |
| | 9H-Pyrido[3,4-b]indole-1-carboxylic acid
Preparation Products And Raw materials |
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