| Company Name: |
Chengdu Kamel Pharmaceutical Co., Ltd
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| Tel: |
028-67136579 15828051124 |
| Email: |
sales@kamelpharm.com |
| Products Intro: |
Product Name:Ethyl 6-methyl-4-(3-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
CAS:110448-29-8
Purity:96% Package:1g;10g;100g Remarks:002428
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Email: |
marketing1@energy-chemical.com |
| Products Intro: |
Product Name:Nifetepimine >=95% (HPLC)
CAS:110448-29-8
Purity:NULL Package:25mg;5mg Remarks:NULL
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| Company Name: |
Hubei wei shi reagent group ltd., company
|
| Tel: |
027-59101766 13125137661 |
| Email: |
2853877621@qq.com |
| Products Intro: |
Product Name:ethyl 6-methyl-4-(3-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
CAS:110448-29-8
Purity:98
|
| Company Name: |
Merck KGaA
|
| Tel: |
(+86) 21 2033 8288 |
| Email: |
sigmaname@qq.com |
| Products Intro: |
Product Name:Nifetepimine
CAS:110448-29-8
|
| Company Name: |
PHARMEKS Ltd.
|
| Tel: |
+7 (495) 702-9648 |
| Email: |
sales@pharmeks.com |
| Products Intro: |
CAS:110448-29-8
Package:5μmol Remarks:C14H15N3O5
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|
| | ethyl 6-methyl-4-(3-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate Basic information |
| Product Name: | ethyl 6-methyl-4-(3-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate | | Synonyms: | Nifetepimine;ethyl 6-methyl-4-(3-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate;ethyl 6-methyl-4-(3-nitrophenyl)-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate;5-Pyrimidinecarboxylic acid, 1,2,3,4-tetrahydro-6-methyl-4-(3-nitrophenyl)-2-oxo-, ethyl ester;Nifetepimine >=95% (HPLC) | | CAS: | 110448-29-8 | | MF: | C14H15N3O5 | | MW: | 305.29 | | EINECS: | | | Product Categories: | | | Mol File: | 110448-29-8.mol |  |
| | ethyl 6-methyl-4-(3-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate Chemical Properties |
| Melting point | 226-227.5 °C | | Boiling point | 444.3±45.0 °C(Predicted) | | density | 1.302±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: 10mg/mL, clear | | pka | 10.86±0.70(Predicted) | | form | powder | | color | white to beige |
| | ethyl 6-methyl-4-(3-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate Usage And Synthesis |
| Biological Activity | Nifetepimine is a dihydropyrimidone calcium channel blocker th at down-modulates SERCA3 (sarco/endoplasmic reticulum Ca2+ -ATPase 3) pump, and protects of the CD4+ T cells from tumor-induced apoptosis. Nifetepimine induces apoptotic cell death in triple negative breast cancer (TNBC) cells by stimulation of cross-talk between ER stress and the MEK/ERK pathway. |
| | ethyl 6-methyl-4-(3-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate Preparation Products And Raw materials |
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