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| | TCS-OX2-29 HCl Basic information |
| Product Name: | TCS-OX2-29 HCl | | Synonyms: | TCS-OX2-29 HCl;(2S)-1-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-3,3-dimethyl-2-(pyridin-4-ylmethylamino)butan-1-one:hydrochloride;TCSOX229 HCl,TCS-OX-2-29 HCl,TCS OX2 29 HCl;TCS-OX2-29 hydrochloride | | CAS: | 1610882-30-8 | | MF: | C23H32ClN3O3 | | MW: | 433.98 | | EINECS: | | | Product Categories: | | | Mol File: | 1610882-30-8.mol |  |
| | TCS-OX2-29 HCl Chemical Properties |
| solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; PBS (pH 7.2): 10 mg/ml | | form | A crystalline solid | | color | White |
| | TCS-OX2-29 HCl Usage And Synthesis |
| Description | Orexin receptors R1 (OX1R) and OX2R mediate the action of the neuropeptides orexin A and orexin B. TCX-OX2-29 is an antagonist of OX2R (pKi = 7.5) that exhibits >250-fold selectivity for hOX2R compared with hOX1R (IC50s = 40 nM and >10,000 nM, respectively). It blocks the inhibitory action of orexin A on forskolin-induced cAMP formation. | | storage | +4°C |
| | TCS-OX2-29 HCl Preparation Products And Raw materials |
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