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ATK CHEMICAL COMPANY LIMITED
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3429815786 13301662590 |
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CAS:1084893-56-0 Purity:98% HPLC Package:1G;5G;10G;25G;50G;100G,1KG;25KG;50KG
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| (S)-CR8 Basic information |
Product Name: | (S)-CR8 | Synonyms: | CR8, (S)-Isomer - CAS 1084893-56-0 - Calbiochem;1-Butanol, 2-[[9-(1-methylethyl)-6-[[[4-(2-pyridinyl)phenyl]methyl]amino]-9H-purin-2-yl]amino]-, (2S)-;CR8, (S)-Isomer | CAS: | 1084893-56-0 | MF: | C24H29N7O | MW: | 431.53 | EINECS: | | Product Categories: | | Mol File: | 1084893-56-0.mol | |
| (S)-CR8 Chemical Properties |
Boiling point | 671.4±65.0 °C(Predicted) | density | 1.27±0.1 g/cm3(Predicted) | storage temp. | +2C to +8C | solubility | DMSO: soluble,Ethanol: soluble | form | Off-white solid | pka | 14.56±0.10(Predicted) | color | White to off-white |
| (S)-CR8 Usage And Synthesis |
Description | (S)-CR8 is a second generation derivative of (R)-roscovitine and an inhibitor of cyclin-dependent kinase 1 (Cdk1/cyclin B), Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p25, and Cdk9/cyclin T (IC50s = 0.15, 0.08, 0.06, 0.12, and 0.11 μM, respectively). It also inhibits casein kinase CK1δ/ε (CKδ/ε) and DYRK1A (IC50s = 0.61 and 0.9 μM, respectively). (S)-CR8 reduces cell viability in human neuroblastoma cell lines, including SH-SY5Y, SK-N-AS, SK-N-BE, and IMR32 cells (IC50s = 0.43, 1.46, 0.13, and 0.14 μM, respectively). It also reduces protein levels of the survival factor Mcl-1 in SH-SY5Y cells. | Definition | ChEBI: (2S)-2-[[9-propan-2-yl-6-[[4-(2-pyridinyl)phenyl]methylamino]-2-purinyl]amino]-1-butanol is a phenylpyridine. |
| (S)-CR8 Preparation Products And Raw materials |
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