114899-80-8
| 中文名称 | 114899-80-8 |
|---|---|
| 中文同义词 | U373MG细胞抑制剂(ECTEINASCIDIN 770);化合物 T11150;曲贝替定杂质3 |
| 英文名称 | Ecteinascidin 770 |
| 英文同义词 | Ecteinascidin 770;Et-770;Ecteinascidine 770;Trabectedin Intermediates N-1;Spiro[6,16-(epithiopropanoxymethano)-7,13-imino-12H-1,3-dioxolo[7,8]isoquino[3,2-b][3]benzazocine-20,1'(2'H)-isoquinoline]-14-carbonitrile, 5-(acetyloxy)-3',4',6,6a,7,13,14,16-octahydro-6',8-dihydroxy-7',9-dimethoxy-4,10,23-trimethyl-19-oxo-, (1'R,6R,6aR,7R,13S,14R,16R)- |
| CAS号 | 114899-80-8 |
| 分子式 | C40H42N4O10S |
| 分子量 | 770.85 |
| EINECS号 | |
| 相关类别 | 细胞生物学试剂 |
| Mol文件 | 114899-80-8.mol |
| 结构式 |  |
114899-80-8 性质
| 密度 | 1.53±0.1 g/cm3(Predicted) |
|---|---|
| 储存条件 | -20°C, protect from light |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 9.65±0.40(Predicted) |
| 形态 | 固体 |
| 颜色 | 白色至米白色 |
IC50: 4.83 nM (U373MG cell); 0.6 nM (HCT116 cell), 2.4 nM (QG56 cell), 0.81 nM (DU145)
Ecteinascidin 770 induces apoptosis of U373MG cells. The IC 50 concentration of ecteinascidin 770 for killing U373MG glioblastoma cells in culture by using the MTT assay is 4.83 nM by a 72 hour-treatment. The IC 50 values against human cell lines HCT116, QG56, and DU145 are 0.6, 2.4, and 0.81 nM, respectively. ET-770 is shown to enhance anoikis response of human lung cancer H23 cells in a dose-dependent manner. Ecteinascidin 770 sensitizes the cells by activating the p53 protein, which in turn down-regulates anti-apoptotic myeloid cell leukemia sequence-1 (MCL1) and up-regulates BCL2-associated X protein (BAX) proteins. However, B-cell lymphoma-2 (BCL2) proteins are not significantly affected by Ecteinascidin 770. The anoikis sensitization of ET-770 is observed in H460 lung cancer cells.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-101191 | 114899-80-8 Ecteinascidin 770 | 114899-80-8 | 5mg | 7500元 |
| 2024/01/25 | HY-101191 | Ecteinascidin 770 | 1 mg | 2600元 |