1639895-85-4
| 中文名称 | 1639895-85-4 |
|---|---|
| 中文同义词 | HIPK2抑制剂(TBID);化合物 T13096;化合物 TBID |
| 英文名称 | tBID |
| 英文同义词 | tBID;1H-Isoindole-1,3(2H)-dione, 4,5,6,7-tetrabromo-2-(1H-imidazol-2-yl)-;4,5,6,7-tetrabromo-2-(1H-imidazol-2-yl)isoindoline-1,3-dione |
| CAS号 | 1639895-85-4 |
| 分子式 | C11H3Br4N3O2 |
| 分子量 | 528.78 |
| EINECS号 | |
| 相关类别 | 细胞生物学试剂 |
| Mol文件 | 1639895-85-4.mol |
| 结构式 |  |
1639895-85-4 性质
| 沸点 | 724.9±70.0 °C(Predicted) |
|---|---|
| 密度 | 2.604±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | DMSO：26 mg/mL（49.17 mM 和升温） |
| 酸度系数(pKa) | 12.01±0.10(Predicted) |
| 形态 | 固体 |
| 颜色 | 浅黄至黄色 |
IC50: 0.33 µM (HIPK2)
Homeodomain-interacting protein kinase 2 (HIPK2) is a Ser/Thr kinase controlling cell proliferation and survival. TBID, displays toward HIPK2 unprecedented efficacy (IC 50 =0.33 µM) and selectivity (Gini coefficient 0.592 out of a panel of 76 kinases). The two other members of the HIPK family, HIPK1 and HIPK3, are also inhibited by TBID albeit less efficiently than HIPK2. The mode of action of TBID is competitive with respect to ATP, consistent with modelling. TBID interacts with the hinge region through hydrophobic interactions between Val 213, Val 261, Phe 277, Leu 280, Met 331, Ile 345, and the tetrabromine moiety, while the symmetric nitrogen atom at position 3 interacts with the catalytic Lys 228, thus playing a crucial role in the binding architecture.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/08/19 | HY-100464 | 1639895-85-4 tBID | 1639895-85-4 | 1mg | 1100元 |
| 2024/08/19 | HY-100464 | 1639895-85-4 tBID | 1639895-85-4 | 5mg | 2850元 |