145841-10-7
中文名称 | 145841-10-7 |
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中文同义词 | 化合物 T12866;化合物 SCH 42495 RACEMATE |
英文名称 | Sch-42495 (racemate) |
英文同义词 | Sch-42495 (racemate);L-Methionine, N-[2-[(acetylthio)methyl]-3-(2-methylphenyl)-1-oxopropyl]-, ethyl ester |
CAS号 | 145841-10-7 |
分子式 | C20H29NO4S2 |
分子量 | 411.58 |
EINECS号 | |
相关类别 | |
Mol文件 | 145841-10-7.mol |
结构式 |
145841-10-7 性质
沸点 | 597.3±50.0 °C(Predicted) |
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密度 | 1.158±0.06 g/cm3(Predicted) |
储存条件 | Store at -20°C |
溶解度 | 溶于二甲基亚砜 |
酸度系数(pKa) | 13.50±0.46(Predicted) |
NEP
SCH 42495 selectively inhibits hydrolysis of leu-enkephalin and ANF (IC 50 of 8.3 and 10.0 nM, respectively) in vitro.
SCH 42495 (30 mg/kg; oral gavage; twice daily) causes a significant reduction in the pulmonary vascular remodelling and ventricular hypertrophy in hypoxic rats after 10 days.
Treatment with SCH 42495 (30 mg/kg; oral gavage; twice daily) leads to a decrease in cardiovascular remodelling secondary to chronic hypoxia in rats.
SCH 42495 (oral doses of 1, 3, or 10 mg/kg) produces significant reductions in blood pressure in DOCA-N a hypertensive rats of 22±6, 43±7, and 62±12 mm Hg, respectively.
Animal Model: | Hypoxic rats |
Dosage: | 30 mg/kg |
Administration: | Oral gavage; twice daily for 10 days |
Result: |
Caused a significant reduction in the pulmonary vascular remodelling and ventricular hypertrophy.
Led to a decrease in cardiovascular remodelling secondary to chronic hypoxia. |