化合物 T22720
| 中文名称 | 化合物 T22720 |
|---|---|
| 中文同义词 | 化合物 T22720;1,2-双(3-氟亚苄基)肼;DFB,MGLU5受体的正变构调节剂;3-氟苯甲醛2-[(3-氟苯基)亚甲基]腙 |
| 英文名称 | DFB |
| 英文同义词 | [(3-FLUOROPHENYL)METHYLENE]HYDRAZONE-3-FLUOROBENZALDEHYDE;3,3'-DIFLUOROBENZALDAZINE;DFB;1-(3-fluorophenyl)-N-[(Z)-(3-fluorophenyl)methylideneamino]methanimine;Benzaldehyde, 3-fluoro-, 2-[(3-fluorophenyl)methylene]hydrazone;3,3' Difluorobenzaldazine,3,3'Difluorobenzaldazine;1,2-Bis(3-fluorobenzylidene)hydrazine;3,3'-Difluorobenzaldazine |
| CAS号 | 15332-10-2 |
| 分子式 | C14H10F2N2 |
| 分子量 | 244.24 |
| EINECS号 | |
| 相关类别 | Glutamate receptor |
| Mol文件 | 15332-10-2.mol |
| 结构式 |  |
化合物 T22720 性质
| 沸点 | 326.6±42.0 °C(Predicted) |
|---|---|
| 密度 | 1.12±0.1 g/cm3(Predicted) |
| 储存条件 | 2-8°C |
| 溶解度 | 二甲基亚砜：~12 mg/mL |
| 酸度系数(pKa) | 5.78±0.50(Predicted) |
| 形态 | 固体 |
| 颜色 | 粘黄色 |
3,3'-Difluorobenzaldazine (DFB) 是一种选择性 mGluR5 正变构调节剂。3,3'-Difluorobenzaldazine 可增强 mGlu5 激动剂 (Glutamate, Quisqualate, 3,5-Dihydroxyphenylglycine) 的 3-6 倍作用，EC50 在 2 到 5 μM 范围内。
3,3'-Difluorobenzaldazine (DFB) causes a concentration-dependent potentiation of the response of human mGluR5 CHO cells to 300 nM glutamate in this assay. The maximal potentiation at this concentration of glutamate is approximately 3.1-fold, with an EC 50 for potentiation of 2.6 μM. 3,3'-Difluorobenzaldazine causes similar potentiation of the responses of both human mGluR5 and rat mGluR5 CHO cells to glutamate, quisqualate, and DHPG with comparable potencies.
3,3'-Difluorobenzaldazine (40-100 nmol; icv) attenuates the locomotor hyperactivity, motor incoordination, and cognitive impairment induced by Ketamine.
| Animal Model: | Male NMRI and ICR mice (8-9 weeks, 33-40 g) |
| Dosage: | 40-100 nmol (~9.7-24.4 μg) |
| Administration: | ICV |
| Result: | Attenuated the locomotor hyperactivity, motor incoordination, and cognitive impairment induced by Ketamine. |
| 提供商 | 语言 |
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