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| | IDH-889 Basic information |
| Product Name: | IDH-889 | | Synonyms: | IDH889;IDH-889;IDH889;IDH-889;IDH 889;Inhibitor,inhibit,Isocitrate Dehydrogenase (IDH),IDH889,IDH 889,IDH-889;2-Oxazolidinone, 3-[2-[[(1S)-1-[5-(4-fluoro-3-methylphenyl)-2-pyrimidinyl]ethyl]amino]-4-pyrimidinyl]-4-(1-methylethyl)-, (4S)- | | CAS: | 1429179-07-6 | | MF: | C23H25FN6O2 | | MW: | 436.48 | | EINECS: | | | Product Categories: | | | Mol File: | 1429179-07-6.mol |  |
| | IDH-889 Chemical Properties |
| Boiling point | 589.5±60.0 °C(Predicted) | | density | 1.284±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | Solid | | pka | 4.15±0.10(Predicted) | | color | White to off-white |
| | IDH-889 Usage And Synthesis |
| Description | IDH889 is a potent and selective inhibitors of IDH1. IDH899 shows IDH (R132H) IC50 = 20 nM; Cell 2-HG IC50 = 14 nM. IDH889 demonstrates significantly improved plasma exposure in mice vs IDH662 (AUC 3.6 μM·h, Cmax 1.7 μM at 10 mg/kg; AUC 55.5 μM·h, Cmax 14.2 μM at 100 mg/kg). IDH889 also has excellent permeability and no efflux in the Caco-2 and human MDR1-MDCK cell lines, supporting the hypothesis that potent inhibition of mutant IDH1 function by binding at the allosteric binding site is compatible with brain penetration. |
| | IDH-889 Preparation Products And Raw materials |
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