| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:BIM-46050
CAS:201487-52-7
Purity:详情请点击官网 Package:1 mg
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| | BIM-46050 Basic information |
| Product Name: | BIM-46050 | | Synonyms: | BIM-46050;L-Methionine, N-[[(4R)-3-[(2S,3S)-2-[[(2R)-2-amino-3-mercaptopropyl]amino]-3-methylpentyl]-5,5-dimethyl-4-thiazolidinyl]carbonyl]- | | CAS: | 201487-52-7 | | MF: | C20H40N4O3S3 | | MW: | 480.75 | | EINECS: | | | Product Categories: | | | Mol File: | 201487-52-7.mol |  |
| | BIM-46050 Chemical Properties |
| Boiling point | 699.7±55.0 °C(Predicted) | | density | 1.162±0.06 g/cm3(Predicted) | | pka | 3.32±0.10(Predicted) |
| | BIM-46050 Usage And Synthesis |
| Description | BIM-46050 is a potent and specific inhibitor of human farnesyltransferase. BIM-46050 is free acidic form of BIM-46068. The IC50 values for in vitro inhibition of human brain FTase indicate that BIM-46050 and the ester form BIM-46068 are potent inhibitors of farnesyltransferase. Their potencies are in the nanomolar range and compare favorably with the compounds B581, FTI-277 and L745,631. B581 is an analog of the tetrapeptide Cys-Val-Phe-Met obtained by replacement of the amino-terminal amide bonds inhibiting processing of farnesylated proteins specifically. FTI-277 is a methyl ester of FTI-276, reported as a preferential inhibitor of FTase over GGTase I (100-fold). L745,631 is a 2-substituted piperazine reported to be a highly selective inhibitor of FTase over GGTase (2,000-fold). The selectivity of BIM-46050 and BIM-46068 for FTase over GGTase is very similar for both compounds (3,000-fold). |
| | BIM-46050 Preparation Products And Raw materials |
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