CGS 15943
| 中文名称 | CGS 15943 |
|---|---|
| 中文同义词 | 9-氯-2-(2-呋喃基) - [1,2,4]三唑并[1,5-C]喹唑啉-5-胺;化合物CGS 15943;CGS 15943,腺苷受体拮抗剂;9-氯-2-(呋喃-2-基)-[1,2,4]三唑并[1,5-C]喹唑啉-5-胺 |
| 英文名称 | CGS 15943 |
| 英文同义词 | CGS 15943;9-chloro-2-(2-furyl)-(1,2,4)triazolo(1,5-c)quinazolin-5-imine;9-Chloro-2-(furan-2-yl)[1,2,4]triazolo[1,5-c]quinazolin-5-amine;9-Chloro-5,6-dihydro-2-(furan-2-yl)[1,2,4]triazolo[1,5-c]quinazolin-5-imine;CGS-15943A;9-CHLORO-2-(2-FURYL)(1,2,4)TRIAZOLO(1,5-C)QUINAZOLIN-5-AMINE;9-CHLORO-2-(2-FURANYL)-[1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-5-AMINE;CGS-15943 ADENOSINE A1 RECEPTOR |
| CAS号 | 104615-18-1 |
| 分子式 | C13H8ClN5O |
| 分子量 | 285.69 |
| EINECS号 | |
| 相关类别 | Adenosine receptor |
| Mol文件 | 104615-18-1.mol |
| 结构式 |  |
CGS 15943 性质
| 熔点 | 278-279 °C |
|---|---|
| 密度 | 1.72±0.1 g/cm3(Predicted) |
| 储存条件 | room temp |
| 溶解度 | 二甲基亚砜：>16 mg/mL |
| 酸度系数(pKa) | 1.23±0.30(Predicted) |
| 形态 | 固体 |
| 颜色 | 白色 |
|
p110γ 1.1 μM (IC 50 ) |
p110δ 8.47 μM (IC 50 ) |
adenosine A1 receptor 3.5 nM (Ki) |
adenosine A2A receptor 4.2 nM (Ki) |
adenosine A2B receptor 16 nM (Ki) |
adenosine A3 receptor 51 nM (Ki) |
CGS 15943 inhibits the kinase activity of the class IB PI3K isoform p110γ with an IC 50 of 1.1 μM and shows slight inhibition on p110δ with an IC 50 of 8.47 μM. CGS 15943 (0-20 μM; 72 hours) inhibits growth of HLF and SK-Hep-1 cells, as well as HepG2 and PLC-PRF-5 cells. CGS 15943 (0-20 μM; 24 hours) reduces the phosphorylation of Akt at its residues Ser473 and Thr308 in HLF and Sk-Hep-1 cells.
Cell Viability Assay
| Cell Line: | HLF, SK-Hep-1, HepG2 and PLC-PRF-5 cells |
| Concentration: | 0 μM; 1 μM; 5 μM; 10 μM; 20 μM |
| Incubation Time: | 24 hours |
| Result: | Inhibited growth of four distinct HCC cell lines. |
Western Blot Analysis
| Cell Line: | HLF and Sk-Hep-1 cells |
| Concentration: | 0 μM; 1 μM; 5 μM; 10 μM; 20 μM |
| Incubation Time: | 24 hours |
| Result: | Inhibited the PI3K/Akt pathway in HLF and Sk-Hep-1 cells |
安全信息
| WGK Germany | 3 |
|---|
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/11/08 | HY-100678 | CGS 15943 | 5 mg | 600元 | |
| 2024/11/08 | HY-100678 | CGS 15943 CGS 15943 | 104615-18-1 | 10mM * 1mLin DMSO | 660元 |