LPEPZBJOKDYZAD-ZEJCXXMWSA-N

LPEPZBJOKDYZAD-ZEJCXXMWSA-N Suppliers list
Company Name: ChemeGen 中国  
Tel: 18818260767
Email: sales@chemegen.com
Products Intro: Product Name:Flufenamic Acid-d4
CAS:1185071-99-1
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
Company Name: Beijing Biocreative Technology Co., Ltd.  
Tel: 15522676233
Email: 3007606172@qq.com
Products Intro: Product Name:Flufenamic Acid-d4
CAS:1185071-99-1
Purity:>99% Package:mg
Company Name: Shanghai Yifei Biotechnology Co. , Ltd.  
Tel: 021-65675885 18964387627
Email: customer_service@efebio.com
Products Intro: Product Name:Flufenamic Acid-d4
CAS:1185071-99-1
Purity:>95% Package:500μg;1mg
Company Name: Hubei Qingbei Yunyan Pharmaceutical Technology Co., Ltd  
Tel: 18162595016
Email: 3287908757@qq.com
Products Intro: Product Name:Flufenamic Acid
CAS:1185071-99-1
Purity:95%+HPLC Package:10mg;25mg;50mg;100mg;200mg
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.com
Products Intro: Product Name:Flufenamic Acid-d4
CAS:1185071-99-1
Purity:详情请点击官网 Package:1 mg
LPEPZBJOKDYZAD-ZEJCXXMWSA-N Basic information
Product Name:LPEPZBJOKDYZAD-ZEJCXXMWSA-N
Synonyms:LPEPZBJOKDYZAD-ZEJCXXMWSA-N
CAS:1185071-99-1
MF:C14H6D4F3NO2
MW:285.254556712
EINECS:
Product Categories:
Mol File:1185071-99-1.mol
LPEPZBJOKDYZAD-ZEJCXXMWSA-N Structure
LPEPZBJOKDYZAD-ZEJCXXMWSA-N Chemical Properties
storage temp. -20°C
solubility DMF: soluble,DMSO: soluble,Methanol: soluble
form A solid
Safety Information
MSDS Information
LPEPZBJOKDYZAD-ZEJCXXMWSA-N Usage And Synthesis
Biological ActivityFlufenamic acid-d4 is intended for use as an internal standard for the quantification of flufenamic acid by GC- or LC-MS. Flufenamic acid is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (IC50s = 3 and 9.3 μM for human COX-1 and COX-2, respectively).1 Flufenamic acid inhibits TNF-α-induced increases in COX-2 levels and NF-κB activation in HT-29 colon cancer cells in a concentration-dependent manner.2 It inhibits calcium influx induced by fMLP or A23187 in human polymorphonuclear leukocytes (PMN) with IC50 values of 29 and 14 μM, respectively.3 Flufenamic acid also activates various ion channels, including transient receptor potential canonical 6 (TRPC6) and the large-conductance calcium-activated potassium channel (KCa1.1).4 It also inhibits various ion channels, including TRPC3 and the cystic fibrosis transmembrane conductance regulator (CFTR). Flufenamic acid (20 mg/kg) reduces increases in intestinal fluid secretion and intestinal barrier disruption in mice infected with the El Tor variant of V. cholerae.5
References1.Warner, T.D., Giuliano, F., Vojnovic, I., et al.Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: A full in vitro analysisProc. Nat. Acad. Sci. USA96(13)7563-7568(1999) 2.Paik, J.H., Ju, J.H., Lee, J.Y., et al.Two opposing effects of non-steroidal anti-inflammatory drugs on the expression of the inducible cyclooxygenase. Mediation through different signaling pathwaysJ. Biol. Chem.275(36)28173-28179(2000) 3.Kankaanranta, H., and Moilanen, E.Flufenamic and tolfenamic acids inhibit calcium influx in human polymorphonuclear leukocytesMol. Pharmacol.47(5)1006-1013(1995) 4.Guinamard, R., Simard, C., and Del Negro, C.Flufenamic acid as an ion channel modulatorPharmacol. Ther.138(2)272-284(2013) 5.Pongkorpsakol, P., Satitsri, S., Wongkrasant, P., et al.Flufenamic acid protects against intestinal fluid secretion and barrier leakage in a mouse model of Vibrio cholerae infection through NF-κB inhibition and AMPK activationEur. J. Pharmacol.79894-104(2017)
LPEPZBJOKDYZAD-ZEJCXXMWSA-N Preparation Products And Raw materials
Tag:LPEPZBJOKDYZAD-ZEJCXXMWSA-N(1185071-99-1) Related Product Information