| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:AG-041R
CAS:159883-95-1
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| Company Name: |
ApexBio Technology
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| Tel: |
+ 1-832-696-8203 |
| Email: |
sales@apexbt.com |
| Products Intro: |
Product Name:AG-041R
CAS:159883-95-1
|
| Company Name: |
Cayman Chemical Company
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| Tel: |
(800) 364-9897 |
| Email: |
cayman@caymanchem.com |
| Products Intro: |
Product Name:AG-041R
CAS:159883-95-1
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| | 2-[(3R)-1-(2,2-diethoxyethyl)-3-[(4-methylphenyl)carbamoylamino]-2-oxoindol-3-yl]-N-(4-methylphenyl)acetamide Basic information |
| | 2-[(3R)-1-(2,2-diethoxyethyl)-3-[(4-methylphenyl)carbamoylamino]-2-oxoindol-3-yl]-N-(4-methylphenyl)acetamide Chemical Properties |
| Melting point | 100-102 °C | | Boiling point | 766.6±60.0 °C(Predicted) | | density | 1.25±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | ≤5mg/ml in DMSO;10mg/ml in dimethyl formamide | | form | crystalline solid | | pka | 10.31±0.20(Predicted) |
| | 2-[(3R)-1-(2,2-diethoxyethyl)-3-[(4-methylphenyl)carbamoylamino]-2-oxoindol-3-yl]-N-(4-methylphenyl)acetamide Usage And Synthesis |
| Biological Activity | ag-041r is a cholecystokinin-b/gastrin receptor (gastrin/cck-b) antagonist [1]. the gastrin/cck-b receptor is a regulator of gastric acid secretion and mucosal growth. the gastrin/cck-b is abundantly expressed in mammalian stomach [2]. | | in vitro | in rabbit primary chondrocytes, ag-041r (0.1 μm) stimulated the cell growth and proliferation, but suppressed with 10 μm. treatment with ag-041r (1 μm) for 28 days accelerated the chondrocyte growth and increased the cell number [1]. in chondrocytes incubated with 0.1 and 1 μm ag-041r, synthesis of gag increased with culture, and amounts accumulated in the composites increased [1]. 10 μm ag-041r might be even toxic to the cells and total rna levels [1]. the ratio of the amounts of two chondroitin sulfate isomers, chondroitin-6-sulfate to chondroitin-4-sulfate, an indicator of cartilage maturation, increased with 1 μm but decreased with 10 μm ag-041r [1]. | | in vivo | in a preclinical toxicological study on rats, oral administration of high dose of ag-041r stimulated systemic cartilage hyperplasia, including the trachea, the intervertebral disk and the articular cartilage. daily intraarticular injection of ag-041r for 3 weeks into rat knee joints also induced cartilage hyperplasia in marginal regions of the femoral condyle without affecting other tissues [1]. | | references | [1] ochi m, kawasaki k, kataoka h, et al. ag-041r, a gastrin/cck-b antagonist, stimulates chondrocyte proliferation and metabolism in vitro[j]. biochemical and biophysical research communications, 2001, 283(5): 1118-1123.
[2] langhans n, rindi g, chiu m, et al. abnormal gastric histology and decreased acid production in cholecystokinin-b/gastrin receptor-deficient mice[j]. gastroenterology, 1997, 112(1): 280-286. |
| | 2-[(3R)-1-(2,2-diethoxyethyl)-3-[(4-methylphenyl)carbamoylamino]-2-oxoindol-3-yl]-N-(4-methylphenyl)acetamide Preparation Products And Raw materials |
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