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2,2,2-trideuterio-1-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]ethanone

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2,2,2-trideuterio-1-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]ethanone Suppliers list
Company Name: Shanghai Hongye Biotechnology Co. Ltd  
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Products Intro: Product Name:Ketoconazole-d3
CAS:1217766-70-5
Purity:>98% Package:1mg;10mg;50mg;100mg;
Company Name: ChemeGen(Shanghai) Biotechnology Co.,Ltd.  
Tel: 18818260767
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Products Intro: Product Name:Ketoconazole-d3
CAS:1217766-70-5
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
Company Name: Nanjing Shizhou Biology Technology Co.,Ltd  
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Products Intro: Product Name:Ketoconazole (acetyl-d3)
CAS:1217766-70-5
Purity:95% Package:50mg；100mg
Company Name: Energy Chemical  
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Products Intro: Product Name:Ketoconazole-d3
CAS:1217766-70-5
Purity:NULL Package:50mg;5mg Remarks:NULL
Company Name: Manhag Testing Technology Co., Ltd  
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Products Intro: Product Name:Ketoconazole-[d3]
CAS:1217766-70-5
Purity:1mg Package:1mg
2,2,2-trideuterio-1-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]ethanone Basic information
Product Name:2,2,2-trideuterio-1-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]ethanone
Synonyms:2,2,2-trideuterio-1-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]ethanone;[2H3]-Ketoconazole;Ketoconazole D3Q: What is Ketoconazole D3 Q: What is the CAS Number of Ketoconazole D3 Q: What is the storage condition of Ketoconazole D3 Q: What are the applications of Ketoconazole D3;Ketoconazole (acetyl-d3)
CAS:1217766-70-5
MF:C26H28Cl2N4O4
MW:531.43
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Mol File:1217766-70-5.mol
2,2,2-trideuterio-1-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]ethanone Structure
2,2,2-trideuterio-1-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]ethanone Chemical Properties
storage temp. Store at -20°C
solubility Chloroform: slightly soluble; Methanol: slightly soluble
form A solid
Safety Information
MSDS Information
2,2,2-trideuterio-1-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]ethanone Usage And Synthesis
DescriptionKetoconazole-d3 is intended for use as an internal standard for the quantification of ketoconazole by GC- or LC-MS. Ketoconazole is a broad-spectrum triazole antifungal agent that has activity against C. albicans, C. krusei, C. tropicalis, C. glabrata, C. parapsilosis, C. neoformans, and A. fumigatus strains (IC50s = 0.031-8 μg/ml).1 It inhibits the fungal cytochrome P450 (CYP) isoform CYP51, also known as lanosterol 14α-demethylase, which arrests ergosterol biosynthesis at the fungal membrane. Ketoconazole also inhibits human CYP3A4 (IC50 = 0.54 μM). Formulations containing ketoconazole have been used in the treatment of fungal infections.
UsesKetoconazole-d3 is the labeled analogue of Ketoconazole (K186000), which inhibits cytochrome P-450 dependent steps in the biosynthesis of steroid hormones in vivo. Antimetastatic and antineoplastic activity. Orally active 5-lipoxygenase and thromboxane synthase inhibitor.
References1. Dilmaghanian, S., Gerber, J.G., Filler, D.G., et al. Enantioselectivity of inhibition of cytochrome P450 3A4 (CYP3A4) by ketoconazole: Testosterone and methadone as substrates Chirality 16(2),79-85(2004).
2,2,2-trideuterio-1-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]ethanone Preparation Products And Raw materials
Tag:2,2,2-trideuterio-1-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]ethanone(1217766-70-5) Related Product Information
Ketoconazole Impurity 3 cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl-4-methylbenzenesulphonate Ketoconazole Impurity 1 KetoconazoleN-Oxide Ketoconazole Impurity 4 2-(2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOL-1-YL METHYL)-1,3-DIOXOLANE-4-METHANOL KETOCONAZOLE INTERMEDIATE rac-trans-Ketoconazole Ketoconazole Ketoconazole Impurity 9 (Ketoconazole Hydroxymethyl Impurity) Ketoconazole Impurity 6 Tosyl chloride cis-1-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine 4-(1-Acetylpiperazin-4-yl)phenol 1,3-Difluorobenzene 2,3-Dehydro Ketoconazole 2',4'-Dichloroacetophenone Ketoconazole-13C-d3