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N-[(2,4-difluorophenyl)methyl]-2'-{[2-(4-methoxyphenyl)acetamido]methyl}-[1,1'-biphenyl]-2-carboxamide

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N-[(2,4-difluorophenyl)methyl]-2'-{[2-(4-methoxyphenyl)acetamido]methyl}-[1,1'-biphenyl]-2-carboxamide Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:A1899
CAS:498577-46-1
Package:25mg;1080USD|5mg;278USD Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd
Tel: +86-18341751992 +86-15382112998
Email: 757984502@qq.com
Products Intro: Product Name:A1899
CAS:498577-46-1
Purity:98 Package:500mg；1g；5g；10g；25g Remarks:Provide customized services
Company Name: Aladdin Scientific
Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Products Intro: Product Name:A 1899
CAS:498577-46-1
Purity:>=98%(HPLC) Package:$84.9/5mg;$152.9/10mg;$331.9/25mg;$596.9/50mg;$1074.9/100mg;Bulk package Remarks:98%(HPLC)
Company Name: Shanghai EFE Biological Technology Co., Ltd.  
Tel: 021-65675885 18964387627
Email: info@efebio.com
Products Intro: Product Name:A1899
CAS:498577-46-1
Purity:98% Package:5mg;10mg;25mg
Company Name: MQ (shanghai) Pharmaceuticals Co., Ltd.  
Tel: 13761635123
Email: 1014988033@qq.com
Products Intro: Product Name:N-[(2,4-Difluorophenyl)methyl]-2'-{[2-(4-methoxyphenyl)acetamido]methyl}-[1,1'-biphenyl]-2-carboxamide
CAS:498577-46-1
Purity:＞95% Package:1G，5G

N-[(2,4-difluorophenyl)methyl]-2'-{[2-(4-methoxyphenyl)acetamido]methyl}-[1,1'-biphenyl]-2-carboxamide manufacturers

  • A1899
  • A1899 pictures
  • $1080.00 / 25mg
  • 2024-10-28
  • CAS:498577-46-1
  • Min. Order:
  • Purity:
  • Supply Ability: 10g
N-[(2,4-difluorophenyl)methyl]-2'-{[2-(4-methoxyphenyl)acetamido]methyl}-[1,1'-biphenyl]-2-carboxamide Basic information
Product Name:N-[(2,4-difluorophenyl)methyl]-2'-{[2-(4-methoxyphenyl)acetamido]methyl}-[1,1'-biphenyl]-2-carboxamide
Synonyms:N-[(2,4-difluorophenyl)methyl]-2'-{[2-(4-methoxyphenyl)acetamido]methyl}-[1,1'-biphenyl]-2-carboxamide;A 1899;[1,1'-Biphenyl]-2-carboxamide, N-[(2,4-difluorophenyl)methyl]-2'-[[[2-(4-methoxyphenyl)acetyl]amino]methyl]-;S 20951;S20951;S-20951;N-(2,4-Difluorobenzyl)-2'-((2-(4-methoxyphenyl)acetamido)methyl)-[1,1'-biphenyl]-2-carboxamide;N-[(2,4-difluorophenyl)methyl]-2'-{[2-(4-methoxyphenyl)acetamido]methyl}-[1,1'-biphenyl]-2-carboxamide
CAS:498577-46-1
MF:C30H26F2N2O3
MW:500.54
EINECS:
Product Categories:
Mol File:498577-46-1.mol
N-[(2,4-difluorophenyl)methyl]-2'-{[2-(4-methoxyphenyl)acetamido]methyl}-[1,1'-biphenyl]-2-carboxamide Structure
N-[(2,4-difluorophenyl)methyl]-2'-{[2-(4-methoxyphenyl)acetamido]methyl}-[1,1'-biphenyl]-2-carboxamide Chemical Properties
Boiling point 756.5±60.0 °C(Predicted)
density 1.238±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Soluble in DMSO
pka13.51±0.46(Predicted)
form powder
color white to beige
Safety Information
MSDS Information
N-[(2,4-difluorophenyl)methyl]-2'-{[2-(4-methoxyphenyl)acetamido]methyl}-[1,1'-biphenyl]-2-carboxamide Usage And Synthesis
Biological ActivityPotent and selective TASK-1 potassium channel blocker th at induces lasting respiratory alkalosis and stimulates breathing in anesthetized rats.




A1899 is a highly potent and selective non-voltage-dependent two-pore domain potassium channel K 2P 3.1 blocker (TASK-1, KCNK3, IC50 = 7 nM in CHO cells) with 10-fold selectivity over TASK-3 and much reduced or little potency towards TASK-2/4 (>8 μM in Xenopus oocytes) and other potassium channels. A1899 specifically blocks TASK-1 currents by 74% in Xenopus oocytes at 100 nM via an open-channel block mechanism. A1899 induces lasting respiratory alkalosis and stimulates breathing in anesthetized rats in vivo (5-25 mg/kg, i.v.). Also mitigates the endothelin-1 induced prolonged action potential duration in cardiomyocytes ( at 200 nM).
storageStore at -20°C
N-[(2,4-difluorophenyl)methyl]-2'-{[2-(4-methoxyphenyl)acetamido]methyl}-[1,1'-biphenyl]-2-carboxamide Preparation Products And Raw materials
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