CYN 154806; CYN154806
中文名称 | CYN 154806; CYN154806 |
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中文同义词 | |
英文名称 | CYN 154806 |
英文同义词 | CYN 154806;CYANAMID 154806;AC-(4-NITRO)PHE-D-CYS-TYR-D-TRP-LYS-THR-CYS-D-TYR-NH2;CYN 154806 TRIFLUOROACETATE SALT;CYANAMID 154806 trifluoroacetate salt;M.W. 1197.35 C56H68N12O14S2;CYN 154806; CYN154806;D-Tyrosinamide, N-acetyl-4-nitro-L-phenylalanyl-D-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-threonyl-L-cysteinyl-, cyclic (2→7)-disulfide |
CAS号 | 183658-72-2 |
分子式 | C56H68N12O14S2 |
分子量 | 1197.34 |
EINECS号 | |
相关类别 | 环肽;Somatostatin receptor |
Mol文件 | 183658-72-2.mol |
结构式 |
CYN 154806; CYN154806 性质
沸点 | 1656.2±65.0 °C(Predicted) |
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密度 | 1.47±0.1 g/cm3(Predicted) |
储存条件 | −20°C |
酸度系数(pKa) | 9.87±0.15(Predicted) |
形态 | 粉末 |
颜色 | 白色至类白色 |
水溶解性 | Soluble to 1 mg/ml in water |
Somatostatin Receptor.
CYN 154806 inhibits SRIF-induced increases in extracellular acidification (EAR) in CHO-K1 cells expressing human sst2 receptors (pKB 7.92). CYN 154806 also blocks SRIF-induced increases [35S]-GTPγS binding in CHO-K1 cell membranes expressing human sst2 receptors as well as rat sst2(a) and rat sst2(b) receptors (pKB 7.81, 7.68 and 7.96, respectively).
CYN 154806 (0.1 mg/kg; i.p.; 20 min before the administration of carbachol (CCh) (30 μg/kg) in M4 KO mice) dose-dependently and significantly reverses the decreases acid response to CCh in M4 but not M3 KO mice.
安全信息
安全说明 | 22-24/25 |
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WGK Germany | 3 |
提供商 | 语言 |
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英文
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