| Company Name: |
Shanghai Hongye Biotechnology Co. Ltd
|
| Tel: |
400-9205774 |
| Email: |
sales@glpbio.cn |
| Products Intro: |
Product Name:CAY10726
CAS:1611446-66-2
Purity:>98% Package:1mg;10mg;50mg;100mg;
|
| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
|
| Tel: |
021-65675885 18964387627 |
| Email: |
customer_service@efebio.com |
| Products Intro: |
Product Name:CAY10726
CAS:1611446-66-2
Purity:98% Package:1mg;5mg;10mg
|
| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:CAY10726
CAS:1611446-66-2
Package:1mg/RMB 560;5mg/RMB 2430;10mg/RMB 4250
|
CAY10726 manufacturers
- CAY10726
-
- $78.00 / 1mg
-
2024-10-28
- CAS:1611446-66-2
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | CAY10726 Basic information |
| Product Name: | CAY10726 | | Synonyms: | CAY10726;Hexadecanoic acid, 16-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-;16-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-hexadecanoicacid | | CAS: | 1611446-66-2 | | MF: | C24H36ClF3N2O3 | | MW: | 493 | | EINECS: | | | Product Categories: | | | Mol File: | 1611446-66-2.mol |  |
| | CAY10726 Chemical Properties |
| Boiling point | 560.9±50.0 °C(Predicted) | | density | 1.176±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 20 mg/ml; DMF:PBS(pH7.2) (1:2): 0.33 mg/ml; DMSO: 5 mg/ml; Ethanol: 12 mg/ml | | form | A crystalline solid | | pka | 4.78±0.10(Predicted) |
| | CAY10726 Usage And Synthesis |
| Description | CAY10726 is an arylurea fatty acid.1 It decreases ATP production by 28% in MDA-MB-231 breast cancer cells when used at a concentration of 10 μM. CAY10726 decreases proliferation and initiates apoptosis in MDA-MB-231 cells via depletion of the phospholipid cardiolipin and its precursor phosphatidylglycerol from the mitochondrial membrane. In vivo, CAY10726 (2.5-40 mg/kg) reduces tumor volume and increases tumor cell apoptosis in a mouse MDA-MB-231 breast cancer xenograft model in a dose-dependent manner. | | References | 1. Rawling, T., Choucair, H., Koolaji, N., et al. A novel arylurea fatty acid that targets the mitochondrion and depletes cardiolipin to promote killing of breast cancer cells J. Med. Chem. 60(20),8661-8666(2017). |
| | CAY10726 Preparation Products And Raw materials |
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