| Company Name: |
Sigma-Aldrich
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| Tel: |
021-61415566 800-8193336 |
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orderCN@merckgroup.com |
| Products Intro: |
Product Name:MLK3 (1-488), active, GST tagged
CAS:153190-46-6
Purity:>=70% (SDS-PAGE) Package:10μg Remarks:SRP5245
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| | MLK3 (1-488), active, GST tagged Basic information |
| | MLK3 (1-488), active, GST tagged Chemical Properties |
| | MLK3 (1-488), active, GST tagged Usage And Synthesis |
| General Description | MLK3 or Mixed-Lineage Kinase 3 is a mitogen-activated protein kinase kinase kinase capable of preferentially activating MAPK8/JNK kinase and functions as a positive regulator of JNK signaling pathway. MLK3 can directly phosphorylate and activate IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. MLK3 is a signal-integrating kinase with conventional MAP3K catalytic activity and additional noncatalytic functions that contribute to RAF/ERK signalling. MLK3 is a component of the BRAF/RAF1 complex and is required for integrity of the complex and for activation of ERK by the complex. |
| | MLK3 (1-488), active, GST tagged Preparation Products And Raw materials |
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