HPV16 E7 (86-93)
| 中文名称 | HPV16 E7 (86-93) |
|---|---|
| 中文同义词 | |
| 英文名称 | HPV16 E7(86-93) |
| 英文同义词 | HPV16 E7(86-93);Thr-Leu-Gly-Ile-Val-Cys-Pro-Ile;L-Isoleucine, L-threonyl-L-leucylglycyl-L-isoleucyl-L-valyl-L-cysteinyl-L-prolyl- |
| CAS号 | 160212-93-1 |
| 分子式 | C37H66N8O10S |
| 分子量 | 815.03 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 160212-93-1.mol |
| 结构式 |  |
HPV16 E7 (86-93) 性质
| 沸点 | 1168.2±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.210±0.06 g/cm3(Predicted) |
| 酸度系数(pKa) | 3.72±0.22(Predicted) |
HPV16 E7 (86-93) specific T cells are expandable upon IVS (in vitro stimulation) with cognate peptide-pulsed dendritic cells (DCs) and are reactive against peptide-pulsed targets or, in case of the E711-20 epitope-specific T cells, against HPV16 E7 expressing CaSki cell line.
For peptide HPV16 E7 (86-93), the only response against K562 cells pulsed with the corresponding peptide was significantly blocked by anti-HLA class I Ab w6/32, which was not the case for HPV16 E7 expressing tumor cell line CaSki. Precursor T cells specific for HPV16 E7 (86-93) peptide is able to differentiate, at least in vitro, into HPVspecific effector cells.
HPV16 E7 peptide-loaded autologous dendritic cells (DCs) are able to stimulate a specific cytotoxic CD8+ T-cell response.
HPV16 E7 (86-93) peptide in IVS culture has specific T cell expansion. The HPV16 E7 (86-93) specific T cells produced does not recognize naturally HPV16 E7 expressing cell line CaSki. HPV16 E7 (86-93) peptides also has similar observations in transgenic mice. The HPV16 E7 (86-93) peptide is able to induce cytotoxic T lymphocyte (CTL) responses if loaded on the antigen presenting HLA class I molecules, but that the peptide appears not to be processed or presented by HPV16 infected cells.