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| | IKKγ NBD Inhibitory Peptide Basic information |
| | IKKγ NBD Inhibitory Peptide Chemical Properties |
| storage temp. | Store at -20°C | | solubility | Soluble in DMSO |
| | IKKγ NBD Inhibitory Peptide Usage And Synthesis |
| Description | IKKγ NBD Inhibitory Peptide is a NEMO-binding domain peptide (NBD peptide) corresponding to the NEMO amino-terminal alpha-helical region, which is shown to block TNF-alpha-induced NF-kB activation[1].
| | Uses | IKKγ NBD Inhibitory Peptide is a highly specific inhibitor NF-κB inhibitor. IKKγ NBD Inhibitory Peptide acts by disrupting the interaction between IKKγ/NEMO-binding domain (NBD) with IKKα and IKKβ, thus blocking TNF-α-induced NF-kB activation. IKKγ NBD Inhibitory Peptide could significantly suppresses inflammation and ameliorate the cerebral ischemia-induced neurological deficits[1][2][3]. | | in vivo | IKKγ NBD Inhibitory Peptide (40 μg/4 μL; ICV; single dose; 2 h before MCAO) exhibits neuroprotective effect with reduction in DNA fragmentation, and its ischemic brain damage reduction mechanism be attributed to reduction in inflammation following ischemic injury in middle cerebral artery occlusion (MCAO) rats model[3].
| Animal Model: | Adult male Sprague-Dawley rats (255 g) with middle cerebral artery occlusion (MCAO)[3] | | Dosage: | 40 μg/4 μL | | Administration: | Intracerebroventricular injection; 2 h before MCAO induction | | Result: | Significantly reduced striatal IL-1b level in IKK-NBD peptide treated rats.
Also resulted in reduced staining of microglial OX-42 and protection of BBB from ischemic insult. |
| | References | [1]. Zhao J, et al. Development of novel NEMO-binding domain mimetics for inhibiting IKK/NF-κB activation. PLoS Biol. 2018 Jun 11;16(6):e2004663. |
| | IKKγ NBD Inhibitory Peptide Preparation Products And Raw materials |
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