| Company Name: |
Riedel-de Haen AG
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| Tel: |
800 558-9160 |
| Email: |
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| Products Intro: |
Purity:recombinant, expressed in E. coli, liquid
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| Company Name: |
SIGMA-RBI
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| Tel: |
800 736 3690 (Orders) |
| Email: |
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| Products Intro: |
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| | RO-52 (SSA) HUMAN Basic information |
| | RO-52 (SSA) HUMAN Chemical Properties |
| storage temp. | -70°C | | form | liquid |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 1 |
| | RO-52 (SSA) HUMAN Usage And Synthesis |
| Uses | RO-52 (SSA) human has been used:
- as a component of the autoantigen array
- to immobilise protein on the self-assembly monolayer
- in enzyme-linked immunosorbent assays (ELISAs)
| | General Description | RO-52 (SSA), also called as tripartite motif-containing protein 21 (TRIM21) is a 52 kDa, ubiquitin E3 ligase. It has a N-terminal RING finger domain (Really Interesting New Gene), crucial for ubiquitination functionality. RO-52 (SSA) gene is mapped to human chromosome 11p5.5. It is capable of autoubiquitination and uniquitylates p62 protein and regulates redox homeostasis. Patients with Sjogren′s syndrome display elevated levels of anti-Ro/SSA antibodies. RO-52 levels in peripheral blood mononuclear cells (PBMC) contributes to pathogenesis of systemic lupus erythematosus (SLE), systemic autoimmune rheumatic diseases (SARDs), interstitial lung disease (ILD) and connective tissue diseases (CTD). RO-52 is considered as potential target for treating SLE. | | Biochem/physiol Actions | Used for the detection and quantification of antibodies to RNPs in rheumatic diseases. |
| | RO-52 (SSA) HUMAN Preparation Products And Raw materials |
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