NKH477
中文名称 | NKH477 |
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中文同义词 | |
英文名称 | N,N-DIMETHYL-(3R,4AR,5S,6AS,10S,10AR,10BS)-5-(ACETYLOXY)-3-ETHENYLDODECAHYDRO-10,10B-DIHYDROXY-3,4A,7,7,10A-PENTAMETHYL-1-OXO-1H-NAPHTHO[2,1-B]PYRAN-6-YL ESTER B-ALANINE HYDROCHLORIDE |
英文同义词 | N,N-DIMETHYL-(3R,4AR,5S,6AS,10S,10AR,10BS)-5-(ACETYLOXY)-3-ETHENYLDODECAHYDRO-10,10B-DIHYDROXY-3,4A,7,7,10A-PENTAMETHYL-1-OXO-1H-NAPHTHO[2,1-B]PYRAN-6-YL ESTER B-ALANINE HYDROCHLORIDE;NKH 477;(3r-(3-alpha,4a-beta,5-beta,6-beta,6a-alpha,10-alpha,10a-beta,10b-alpha))-id;N,N-dimethyl-, (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho[2,1-b]pyran-6-yl ester b-Alanine hydrochloride;Forskolin, NKH477;beta-alanine,n,n-dimethyl-,5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydrox;colforsindapropatehydrochloride;N,N-Dimethyl-(3R,4aR,5S,6aS,10S,10aR,10bS)-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho[2,1-b]pyran-6-yl ester beta-alanine hydrochloride |
CAS号 | 138605-00-2 |
分子式 | C27H44ClNO8 |
分子量 | 546.1 |
EINECS号 | |
相关类别 | Signalling;Cyclic Nucleotide related |
Mol文件 | 138605-00-2.mol |
结构式 |
NKH477 性质
储存条件 | 2-8°C |
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溶解度 | H2O:3mg/mL,清澈至轻微混浊(加热) |
形态 | 白色固体 |
颜色 | 白色至米色 |
水溶解性 | Soluble to 40 mM in water |
NKH477 (Colforsin dapropate hydrochloride) 是一种新型水溶性毛喉素衍生物,主要通过对舒张性心脏功能的有益作用来改善心力衰竭。 NKH477 直接激活腺苷酸环化酶 (adenylate cyclase) 的催化单元并增加细胞内 cAMP。 NKH477 在体内抗增殖作用,可以抑制大鼠原位肺同种异体移植物的急性排斥。
Adenylate Cyclase
NKH477 (Colforsin dapropate hydrochloride) (orally; 1-3 mg/kg/day; days 3 and 5) prolonged lung allograft survival in a dose dependent manner.
Animal Model: | Specific-pathogen-free inbred male Lewis rats (LEW) weighing 250 to 280 g |
Dosage: | 1, 2 or 3 mg/kg/day |
Administration: | Orally; daily; Days 3 and 5 |
Result: | Prolonged lung allograft survival in a dose dependent manner. |
安全信息
危险品标志 | T+ |
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危险类别码 | 28 |
安全说明 | 28-36/37-45 |
危险品运输编号 | UN 2811 6.1 / PGII |
WGK Germany | 3 |
RTECS号 | AY5992600 |
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-103193 | NKH477 NKH477 | 138605-00-2 | 5mg | 1000元 |
2024/08/19 | HY-103193 | NKH477 NKH477 | 138605-00-2 | 10mg | 1800元 |